Factor XI promotes hemostasis in factor IX-deficient mice

Journal of Thrombosis and Haemostasis : JTH
B M MohammedDavid Gailani

Abstract

Essentials Mice lacking factor IX (FIX) or factor XI (FXI) were tested in a saphenous vein bleeding model. FIX-deficient mice displayed a hemostatic defect and FXI-deficient mice were similar to wild type mice. Infusion of FXI or over-expression of FXI in FIX-deficient mice improved hemostasis. FXI may affect the phenotype of FIX-deficiency (hemophilia B). Background In humans, deficiency of coagulation factor XI may be associated with a bleeding disorder, but, until recently, FXI-deficient mice did not appear to have a hemostatic abnormality. A recent study, however, indicated that FXI-deficient mice show a moderate hemostatic defect in a saphenous vein bleeding (SVB) model. Objectives To study the effect of FXI on bleeding in mice with normal levels of the FXI substrate FIX and in mice lacking FIX (a murine model of hemophilia B). Methods Wild-type mice and mice lacking either FIX (F9- ) or FXI (F11-/- ) were tested in the SVB model. The plasma levels of FXI in F11-/- mice were manipulated by infusion of FXI or its active form FXIa, or by overexpressing FXI by the use of hydrodynamic tail vein injection. Results F9- mice showed a significant defect in the SVB model, whereas F11-/- mice and wild-type mice were indistinguishabl...Continue Reading

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Citations

Sep 4, 2019·Journal of Thrombosis and Haemostasis : JTH·Alisa S Wolberg
May 28, 2019·Journal of Thrombosis and Haemostasis : JTH·Bassem M MohammedDavid Gailani
Jul 12, 2019·Research and Practice in Thrombosis and Haemostasis·Vikram RaghunathanJoseph J Shatzel

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