PMID: 6168728Jun 1, 1981Paper

Factor XII assay with the chromogenic substrate chromozym PK

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
W DickK Adler

Abstract

A chromogenic assay for the determination of factor XII using the chromogenic substrate Chromozym PK was evaluated. The assay was linear in the range 10 U/l to more than 200 U/l. Using the assay, the normal range of factor XII (50 healthy volunteers at random) was 136 U/l +/- 27 U/l. Kallikrein-inhibiting concentrations of aprotinin did not influence factor XII. Comparison of the chromogenic with the clotting assay resulted in a correlation coefficient of r = 0.831 (p-value less than 0.001). In patients with deep vein thrombosis, factor XII level was found to be reduced to about 60% of normal activity.

References

Nov 1, 1976·Thrombosis Research·A M VennerödS Strömland
Dec 1, 1973·The Journal of Experimental Medicine·C G CochraneK D Wuepper
Jul 1, 1965·Biochimica Et Biophysica Acta·J G SchoenmakersF Zilliken
Jun 1, 1958·American Journal of Clinical Pathology·N F RODMANJ B GRAHAM
Apr 1, 1955·The Journal of Clinical Investigation·O D RATNOFF, J E COLOPY

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
W Cullmann, W Dick
Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
W Dick, W Cullmann
Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
J Chmielewska, Z S Latallo
Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
G VogelG Lauten
© 2021 Meta ULC. All rights reserved