Factor XII but not protein C, protein S, antithrombin III, or factor XIII is a predictor of recurrent miscarriage

Fertility and Sterility
M OgasawaraK Suzumori

Abstract

To investigate whether a decrease in the values of protein C (PC), protein S (PS), antithrombin III (ATIII), factor XII (FXII), or factor XIII (FXIII) has predictive value for subsequent miscarriages. Prospective study. Nagoya City University Medical School. A total of 536 patients with a history of two or more first-trimester miscarriages. One hundred and twelve patients treated with low-dose aspirin were excluded from the analysis. The subsequent pregnancy outcome of 424 patients was compared for abnormal and normal levels of each parameter. There were no differences in the subsequent miscarriage rates between abnormal and normal values of PC, PS, ATIII, and FXIII. However, the rate with abnormal FXII is significantly higher than that with normal FXII. A decrease in FXII (but not in PC, PS, ATIII, or FXIII) predicts subsequent miscarriage in patients with a history of first-trimester recurrent miscarriages.

References

Sep 1, 1990·British Journal of Haematology·R G MaliaF E Preston
Jul 28, 1984·Lancet·R G FarquharsonL John
Oct 28, 1995·Lancet·D C ReesJ B Clegg
Aug 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M OgasawaraY Yagami
Feb 1, 1996·British Journal of Haematology·R RaiH Cohen
Oct 5, 1996·Lancet·F E PrestonF J van der Meer

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Citations

May 21, 2005·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Dec 4, 2001·Fertility and Sterility·D W JonesM Winter
Sep 13, 2003·Fertility and Sterility·Hans-Ulrich PauerBernd Hinney
Aug 25, 2009·Reproduction, Fertility, and Development·Hiroaki KawatoNorimasa Sagawa
Jan 26, 2005·American Journal of Reproductive Immunology : AJRI·Mayumi Sugiura-OgasawaraKaoru Suzumori
Mar 12, 2004·American Journal of Ophthalmology·Claudia KuhliLars-Olof Hattenbach
Jun 23, 2006·Human Reproduction·Mayumi Sugiura-OgasawaraYasuhiko Ozaki
Jun 19, 2007·Trends in Molecular Medicine·Kwang-Hyun BaekYong-Soo Kim
Sep 12, 2006·Obstetrics and Gynecology Clinics of North America·Howard J A Carp
Sep 20, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Katharina WalchGertrud Unfried
Nov 20, 2004·Journal of Thrombosis and Haemostasis : JTH·J P AntovicM Blombäck
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Tina Buchholz, Christian J Thaler
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Tina BuchholzChristian J Thaler
Feb 26, 2008·American Journal of Reproductive Immunology : AJRI·Hidehiko MatsubayashiMikio Mikami
Sep 12, 2007·American Journal of Reproductive Immunology : AJRI·Yukio HattoriMayumi Sugiura-Ogasawara
Mar 14, 2008·American Journal of Reproductive Immunology : AJRI·Kyoko KumagaiMayumi S Ogasawara
Jan 3, 2013·Journal of Thrombosis and Haemostasis : JTH·V Schroeder, H P Kohler
Feb 15, 2012·Journal of Thrombosis and Haemostasis : JTH·E PasquierV Schroeder
Feb 20, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yasushi MatsukawaMayumi Sugiura-Ogasawara
May 2, 2007·Obstetrics and Gynecology·Alexandros SotiriadisSophia N Kalantaridou
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Mayumi Sugiura-OgasawaraKyoko Kumagai
Dec 18, 2008·American Journal of Reproductive Immunology : AJRI·Mayumi Sugiura-OgasawaraYasuhiko Ozaki
Dec 24, 2010·Nihon rinsho. Japanese journal of clinical medicine·Mayumi SugiuraKinue Katano
Jul 12, 2011·Physiological Reviews·László MuszbekÉva Katona
Apr 24, 2014·The Journal of Obstetrics and Gynaecology Research·Mayumi Sugiura-OgasawaraNobuhiro Suzumori
Aug 4, 2009·Reproductive Medicine and Biology·Mayumi Sugiura-OgasawaraTamao Kitaori
Feb 1, 2008·Reproductive Medicine and Biology·Aiko Makino, Mayumi Sugiura-Ogasawara
Apr 4, 2021·International Journal of Molecular Sciences·Fahad S M AlshehriNicola J Mutch
Jun 26, 2021·The Journal of Obstetrics and Gynaecology Research·Takao KobayashiToshiyuki Miyata
Jul 25, 2021·Journal of Clinical Medicine·Adrianna MarcinkowskaMarcin Rozalski

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