Factor XIII Val34Leu polymorphism in primary intracerebral haemorrhage

The Hematology Journal : the Official Journal of the European Haematology Association
J CorralVicente Vicente

Abstract

Recently, the common Val34Leu polymorphism of the A-chain factor XIII gene, associated with high factor XIII activity, has been identified as a protective genetic factor against occlusive arterial and venous diseases. Moreover, this polymorphism has been suggested to be the first one to increase the risk of cerebral haemorrhage in a small number of Caucasian patients. The aim of our study was to investigate the role of this polymorphism in patients with primary intracerebral haemorrhage from a distinct population. Patients with non-traumatic primary intracerebral haemorrhage (n=116), age-, race-, sex- and risk factor-matched controls (n=116), and individuals from the general population (n=465) were genotyped for the factor XIII Val34Leu polymorphism by polymerase chain reaction and allele specific restriction assay. The relationships of the Val/Leu genotype with distinct intracerebral haemorrhagic risk factors and with early mortality associated with the haemorrhagic episode were also analysed. No statistical difference in terms of prevalence was detected between patients (P=0.190) and controls (P=0.181). The frequency of the FXIII Leu34 allele was similar in the general population (P=0.191). The results suggest that the Leu 34...Continue Reading

Citations

Dec 12, 2001·Cephalalgia : an International Journal of Headache·J A IniestaV Vicente
Mar 25, 2010·Immunogenetics·Lei WanTse Wen Chang
Aug 8, 2009·Neurological Research·Susanna MoskauMichael Linnebank
Aug 23, 2012·International Journal of Laboratory Hematology·B AntalfiA H Shemirani

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