Factors affecting 1H NMR spectra of blood plasma: cancer, diet and freezing

NMR in Biomedicine
J D BellD R Newell

Abstract

Single pulse and Hahn spin-echo 400 and 500 MHz 1H NMR spectra from normal subjects and cancer patients are reported. No significant difference was found between the average -CH3 and -(CH2)n- lipoprotein linewidths of the two groups in contrast to a previous report. Such measurements are shown to be complicated by freezing and thawing of samples which broadens lipoprotein resonances, and by eating which sharpens them. Deconvolution of the composite lipoprotein signals enables these effects to be interpreted. Other notable features of plasma spectra are discussed including resonances for 'acute-phase' glycoproteins, ketone bodies and other small molecules.

References

Nov 27, 1986·The New England Journal of Medicine·E T FosselJ McDonagh
Mar 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R BalesR Williams
May 28, 1987·The New England Journal of Medicine·A Ulmann
Oct 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T L DowdP Aisen
Jun 1, 1983·The Biochemical Journal·J K NicholsonP J Sadler

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Citations

Oct 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F G HerringK P Whittal
Mar 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M EugeneC Cabrol
Jul 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y HiltunenK Kiviniitty
Dec 1, 1989·NMR in Biomedicine·J D BellP J Sadler
Apr 1, 1995·Applied Biochemistry and Biotechnology·S MaC C Huang
Apr 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·P J FoxallJ K Nicholson
Nov 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mika Ala-Korpela
Aug 1, 1988·FEBS Letters·J D BellP J Sadler
Jul 1, 1989·NMR in Biomedicine·G Sutherland, J Peeling
Oct 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·M SpraulE Rahr

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