Factors affecting bronchodilator delivery in mechanically ventilated adults

Nursing in Critical Care
Arzu Ari, James B Fink

Abstract

Bronchodilators are increasingly being used in patients undergoing mechanical ventilation. There are multiple factors that affect bronchodilator delivery during mechanical ventilation. These factors can be classified into three categories: ventilator-related factors, circuit-related factors and device-related factors. The purpose of this paper is to review in depth each of the factors affecting bronchodilator delivery during mechanical ventilation. A literature search was undertaken using several databases including Cochrane, Pubmed, Medline, Cinahl and Science Direct. The literature search, although limited to the English language, covered materials from 1985 to May 2009. Aerosolized bronchodilator delivery to mechanically ventilated patients is complex as a result of the multiple factors that affect the amount of aerosol deposited in the lower respiratory tract. When these factors are not carefully controlled and the optimum technique for aerosol delivery is not utilized, a greater proportion of the aerosol will deposit in the ventilator circuits and artificial airways decreasing the available dose to the patient. Attention to these factors and optimizing aerosol delivery techniques will help to reach therapeutic endpoints of...Continue Reading

References

May 1, 1992·The American Review of Respiratory Disease·T G O'RiordanG C Smaldone
Feb 1, 1992·Chest·G F AlvineR C Ahrens
Feb 1, 1990·The American Review of Respiratory Disease·H D FullerM T Newhouse
Jul 1, 1989·Experimental Lung Research·M SvartengrenP Camner
Jun 1, 1989·Anesthesiology·S J Crogan, M J Bishop
Jan 1, 1986·Pediatric Pulmonology·R C AhrensJ A Wiese
Feb 1, 1985·Critical Care Medicine·N R MacIntyreR E Coleman
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·P DiotG C Smaldone
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·R DhandM J Tobin
Dec 1, 1994·Chest·D T LoffertH S Nelson
May 1, 1994·Respiratory Medicine·G D Phillips, F J Millard
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·T G O'RiordanG C Smaldone
Oct 1, 1993·The American Review of Respiratory Disease·S H ThomasT O Nunan
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·J B FinkM J Tobin
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·R DhandM J Tobin
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R Dhand, M J Tobin
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D TassauxJ C Chevrolet
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·D GeorgopoulosM Klimathianaki
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·M L GoodeM J Tobin
Aug 2, 2003·American Journal of Respiratory and Critical Care Medicine·Dorisanne D MillerGerald C Smaldone
Apr 29, 2008·Clinics in Chest Medicine·Rajiv Dhand, Vamsi P Guntur
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rajiv Dhand
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Claude GuerinJean-Christophe Richard

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Citations

Aug 4, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Arzu AriRajiv Dhand
Jun 14, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·L PitanceG Liistro
Feb 13, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jean-Bernard MichotteGrégory Reychler
Dec 23, 2010·Expert Opinion on Drug Delivery·Remigius U Agu, Michael I Ugwoke
Apr 26, 2013·Expert Opinion on Drug Delivery·James Fink, Arzu Ari
Nov 19, 2011·Journal of Pharmaceutical Sciences·Warangkana PornputtapitakCory Berkland
Feb 26, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Laurent PitanceGiuseppe Liistro
Jan 1, 2014·International Journal of Pharmaceutics·Warangkana PornputtapitakCory Berkland
Jul 23, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nabile BoukhettalaLaurent Vecellio
Jun 17, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jean-Bernard MichotteGrégory Reychler
Jul 23, 2016·Annals of Intensive Care·Jonathan DugernierPierre-François Laterre
Oct 19, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Benny FengHak-Kim Chan
Oct 19, 2017·Expert Opinion on Drug Delivery·Alejandro RodríguezLaurent Vecellio
Jan 5, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anne-Laure Sidler-MoixErmindo R Di Paolo
Nov 13, 2019·The Journal of Pharmacy and Pharmacology·Kazunori KadotaYuichi Tozuka
Jul 22, 2010·Nursing in Critical Care·Julie Scholes, John Albarran
Oct 24, 2017·Critical Care : the Official Journal of the Critical Care Forum·Jonathan DugernierGregory Reychler
Aug 14, 2020·International Journal of Environmental Research and Public Health·Seán M Cunningham, David A Tanner
Jan 22, 2020·Expert Opinion on Drug Delivery·Arzu Ari, James B Fink

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