PMID: 15379421Sep 24, 2004Paper

Factors affecting catch-up growth after liver transplantation

Journal of Pediatric Endocrinology & Metabolism : JPEM
Jesús Alberto López-EspinosaAntonio Carrascosa-Lezcano

Abstract

The reported incidence of catch-up growth following orthotopic liver transplantation (OLT) ranges widely, from 0% to 97%. We undertook bivariate analysis of multiple factors that might affect post-OLT growth in children undergoing OLT, and described the results with different parameters used to determine catch-up growth. Eighty patients met the inclusion criteria. Catch-up growth occurred in 14% during the first 6 months, 15% at 1 year, 39% at 2 years, 16% between 3 and 6 years, and 16% after 6 years post-OLT. The earlier catch-up growth was shown in metabolic diagnosis, patients over 10 years old and those without steroids at 1 year post-OLT. It is difficult to determine an acceptable definition of catch-up growth. We suggest that Zvel score > or =0 is the best parameter to evaluate catch-up growth, since the results are more normally distributed. Patients with prednisone withdrawal later than 1 year post-OLT and those with diagnosis of hepatitis and cirrhosis showed the slowest catch-up growth.

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Citations

May 22, 2007·Current Gastroenterology Reports·William R Treem
Nov 29, 2008·Pediatric Transplantation·Siham Al-Sinani, Anil Dhawan
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R GrendaN J A Webb
Nov 9, 2011·Journal of Pediatric Gastroenterology and Nutrition·Ekkehard Sturm
Oct 28, 2017·Journal of Pediatric Gastroenterology and Nutrition·Nathalie LoebGlenda Courtney-Martin
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Rene ScheenstraPieter J J Sauer
Jun 15, 2021·Expert Opinion on Drug Metabolism & Toxicology·Kathleen M JobCatherine M Sherwin

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