Factors affecting efficacy and safety of add-on combination chemotherapy for non-small-cell lung cancer: a literature-based pooled analysis of randomized controlled trials.

Lung
Kouichi InoueMasahiro Takeuchi

Abstract

Several clinical trials of chemotherapy for non-small-cell lung cancer (NSCLC) have been conducted to date. However, these studies have not been effective at identifying category 1 recommended strategies for systemic chemotherapy according to the National Comprehensive Cancer Network clinical practice guidelines. To investigate the factors that influence the efficacy and safety of add-on combination chemotherapy for NSCLC based on published reports, we searched the PubMed and EMBASE for reports of randomized, controlled trials that compared efficacy and safety between groups with and without the use of add-on drugs to base chemotherapy in patients with NSCLC. For all the selected articles, we systematically retrieved and assessed the full published report. Of the 753 citations yielded by the electronic search, 82 comparison pairs from 76 articles were selected. The logistic regression analysis showed the second- or third-line treatment for target patients (Line2_3), dose modification of the base drug(s) in the investigational arm, characteristics of the add-on drug, and the number of total combination drugs that had negative coefficients, and the percent of patients with performance status 2 who had positive coefficients for ef...Continue Reading

References

Mar 1, 1993·Current Opinion in Oncology·F A Shepherd
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A B SandlerL H Einhorn
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FrasciM De Lena
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U GatzemeierG Gallant
Feb 6, 2003·British Journal of Cancer·S NegoroUNKNOWN CPT-11 Lung Cancer Study Group West
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V AlberolaUNKNOWN Spanish Lung Cancer Group
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstDavid H Johnson
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E R O'BrienUNKNOWN SR-ON-12 Study Group
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E LaackUNKNOWN German and Swiss Lung Cancer Study Group
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vassilis GeorgouliasAthanasios Alegakis
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rogerio C LilenbaumMark R Green
Jan 26, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PectasidesS A Raptis
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Donald BissettFrances A Shepherd
Jul 19, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ageliki RaptiUNKNOWN Lung Cancer Committee of the Hellenic Oncology Research Group (HORG)
Jul 27, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstUNKNOWN TRIBUTE Investigator Group
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christer SederholmSulochana R Gawande
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K WilliamsonUNKNOWN Southwest Oncology Group Trial S0003
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adriano PaccagnellaMaria Grazia Ghi
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hiroyasu YasudaHidetada Sasaki
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luis Paz-AresDavid R Gandara
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rogerio LilenbaumPhillip Bonomi
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P FanucchiJoan H Schiller
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulrich GatzemeierJoachim Von Pawel
Sep 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kun-Ta ChouJacqueline Whang-Peng
Sep 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vassilis GeorgouliasDimitris Mavroudis
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John V HeymachRoy S Herbst
Dec 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles A ButtsFrances A Shepherd
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuh-Min ChenJacqueline Whang-Peng
Apr 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George R BlumenscheinAndres Negro-Vilar

❮ Previous
Next ❯

Citations

Dec 3, 2014·Thoracic Surgery Clinics·Robert J Downey
Sep 18, 2013·Medicine and Science in Sports and Exercise·Lea KuehrMichael Thomas
Oct 15, 2013·Advanced Drug Delivery Reviews·Tamara MinkoVitaly Pozharov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.