Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Takashi Hitsumoto, Kohji Shirai

Abstract

The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients. We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome. There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01), blood concentrations of brain natriuretic peptide (P<0.01), reactive oxygen metabolites (markers of oxidative stress, P<0.001), and the cardio-ankle vascular index (marker of arterial function, P<0.01). Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor. The findings of this study indi...Continue Reading

Citations

Dec 25, 2016·Diabetes & Metabolic Syndrome·Alexander E Berezin
Dec 18, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Esmé Jansen van VurenNicolaas T Malan
Oct 4, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Assi MilwidskyOri Rogowski
Jul 31, 2019·International Journal of Molecular Sciences·Takayuki NambaTakeshi Adachi

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