PMID: 9167094Jan 1, 1997Paper

Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
A Havemose-Poulsen, P Holmstrup

Abstract

Fibroblasts have been studied extensively for their contribution to connective tissue destruction in diseases where the metabolism of extracellular matrix components plays an essential part in their pathogenesis. A considerable dissolution, especially of collagen fibrils, is a well-known characteristic of the periodontal ligament and the gingival connective tissue in microbial-induced periodontal disease. Fibroblasts, responsible for the assembly of the extracellular matrix, are capable of responding directly to oral microbial challenges or indirectly, following activation of the host immune response, and can alter the composition of connective tissue in several ways: synthesis of inflammatory mediators, their receptors and antagonists; fibroblast proliferation; collagen synthesis; phagocytosis of collagen fibrils; and synthesis of proteolytic enzymes, including matrix metalloproteinases and their corresponding inhibitors. The contributions of these cellular fibroblastic properties to the pathogenesis of periodontal disease are reviewed in the context of the cytokine, interleukin-1, as the inflammatory regulator.

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Citations

May 11, 2002·The Proceedings of the Nutrition Society·Dean V Sculley, Simon C Langley-Evans
Oct 20, 1998·Journal of Periodontal Research·A Havemose-PoulsenH Birkedal-Hansen
Jan 21, 2011·Journal of Dental Research·M V Thomas, D A Puleo
Aug 20, 2002·Japanese Journal of Pharmacology·Yukio OzakiYuzo Kato
Aug 14, 2013·PloS One·Dhaarmini RajshankarChristopher A McCulloch
Feb 21, 2003·Journal of Periodontology·Shogo TakashibaYoji Murayama
Apr 25, 2009·The American Journal of Pathology·Alan A ThomayJorge E Albina
Nov 1, 2013·Journal of Periodontology·Holly McKnightAngelo Mariotti
May 16, 2012·Journal of Clinical Periodontology·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Aug 13, 2013·Periodontology 2000·Yongqiang WangChristopher A McCulloch
Sep 8, 2011·Biomedical Chromatography : BMC·Armando CaseiroFrancisco Amado
Apr 9, 2013·Journal of Clinical Periodontology·Ahmed R El-AwadyRegina L W Messer
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L A BorthwickA J Fisher
Sep 12, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shyh-Jye LinChi-Chiang Yang
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Okada, S Murakami
Oct 29, 2003·The Journal of Biological Chemistry·Xiaozhe Han, Salomon Amar
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Feb 23, 2013·Biomedical Research·Naoki TakizawaKoji Naruishi
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·R J Lamont, H F Jenkinson
Jul 10, 2003·Dental Clinics of North America·Palle HolmstrupNils-Erik Fiehn

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