PMID: 8466295Jan 1, 1993Paper

Factors affecting inter-individual variation in human plasma cholinesterase activity: body weight, height, sex, genetic polymorphism and age

Archives of Environmental Contamination and Toxicology
A Brock, V Brock

Abstract

The influence of body weight, height, age and sex on plasma cholinesterase activity (ChE) in 650 males and 437 females with ChE-1 phenotype U (genotype ChEuChEu or ChEuChEs) or UA (genotype ChEuChEa) was studied in a multiple regression model. ChE was not influenced by age (p > 0.01), but, like other liver synthesized plasma enzymes, highly (p < 0.001) influenced by body weight and height. In a logarithmic scale ChE followed a linear model (R = 0.535, p < 0.001) with randomly distributed residuals, InChE = 3.286-0.308 x ChE-1 phenotype-0.104 x sex + 0.00765 x weight - 0.00723 x height (U = 1, UA = 2; male = 1, female = 2; kg; cm). A simplified model based on body-mass index (BMI = weight divided by squared height, kg/m2), InCHE = 2.016-0.308 x ChE-1 phenotype - 0.091 x sex + 0.0230 x BMI, showed the same goodness-of-fit (R = 0.533). In a non-logarithmic scale both multiple regression models failed to fit cases with high ChE activity. A model for a 'standardized' plasma ChE in which the effects of ChE-1 phenotype, sex, body weight and height are eliminated, is proposed to compare ChE in unmatched population groups when using this enzyme activity as a biomarker in environmental or occupational medicine.

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Citations

Dec 4, 1998·Annales Françaises D'anesthèsie Et De Rèanimation·C LejusR Souron
Dec 14, 2011·International Journal of Environmental Health Research·Karine Rigon ZimmerFlávia Vallãdao Thiesen
Feb 1, 1995·Acta Anaesthesiologica Scandinavica·F S JensenJ Viby-Mogensen
Jan 1, 2011·Archives of Environmental & Occupational Health·Zeynel SutolukIsmail Hant
Jan 30, 2014·International Journal of Environmental Research and Public Health·Yutaka AokiPaul T Strickland
Aug 12, 2014·Free Radical Biology & Medicine·Thomas J van 't ErveGarry R Buettner
Nov 24, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Edward R Laskowski
Apr 7, 2015·Mayo Clinic Proceedings·Pedro A VillablancaJames A Levine

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