Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia

Reproductive Biology and Endocrinology : RB&E
Osamu InoueDaisuke Aoki

Abstract

Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilation and curettage (D&C) and endometrial biopsy (EMB), which could result in endometritis, endometrial thinning, or intrauterine adhesion. In turn, any of these outcomes could adversely affect implantation and pregnancy development. The current study thus aimed to identify factors that might affect pregnancy following conservative treatment by MPA. We compared a pregnancy group (45 patients) with a non-pregnancy group (53 patients) of MPA-treated patients to evaluate the factors affecting clinical pregnancy establishment. We undertook a multivariate logistic regression analysis based on factors shown by univariate analysis to be significantly different between the groups. Univariate analysis identified number of D&C, endometrial thickness, duration of MPA administration, age of pregnancy permission (the age at which a patient was first allowed to attempt pregnancy after disappearance of the lesion), period of disappearance of ...Continue Reading

References

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Citations

Nov 10, 2017·The Journal of Obstetrics and Gynaecology Research·Satoshi TamauchiFumitaka Kikkawa
Aug 24, 2019·Archives of Gynecology and Obstetrics·Myung Joo KimYou Shin Kim
Jan 15, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Su Hyun ChaeSoon-Beom Kang
Oct 7, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Christina N Cordeiro MitchellMindy S Christianson
May 21, 2021·Molecular Reproduction and Development·Qiaoying LvXiaojun Chen
Jul 29, 2021·Reproductive Biomedicine Online·Maïlys VaugonMartin Koskas

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Methods Mentioned

BETA
hysterectomy
bilateral oophorectomy
biopsy

Software Mentioned

SPSS

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