PMID: 43277Jan 1, 1979

Factors affecting protein synthesis during biotin deficiency in Aspergillus nidulans

Folia Microbiologica
J D Desai

Abstract

Biotin deficiency in Aspergillus nidulans resulted in a 70% increase of the protein content and increased levels of free and bound aspartate, glutamate, serine, leucine and methionine. Likewise, the activities of NADP+ glutamate dehydrogenase, NAD+ gluatmate dehydrogenase, aspartate aminotransferase and alanine aminotransferase were significantly increased. The total RNA content increased while the DNA content was unaffected. The rRNA/tRNA ratio remained higher in biotin-deficient cells. Supplementation of glutamate, aspartate, serine, leucine and methionine to the culture medium raised the rRNA/tRNA ratio, and the difference observed in the qualitative and the quantitative patterns of protein and dry cell mass between normal and biotin-deficient cultures was abolished.

Citations

Dec 15, 1977·Experientia·J D Desai, V V Modi
Jun 1, 1975·Canadian Journal of Microbiology·J D Desai, V V Modi
Sep 1, 1968·International Journal of Nursing Studies·D P Short
Oct 19, 1973·Archiv für Mikrobiologie·J A Van Assche, A R Carlier
Jun 15, 1970·Experientia·K K Rao, V V Modi
Apr 8, 1971·Biochimica Et Biophysica Acta·H Ishikawa, R W Newburgh
Jul 1, 1968·Canadian Journal of Microbiology·K K Rao, V V Modi
Apr 1, 1956·Journal of General Microbiology·N C PILLAI, K S SRINIVASAN
Mar 1, 1962·Journal of Molecular Biology·N SUEOKA, T Y CHENG
Feb 1, 1964·Journal of Bacteriology·R H DOI, R T IGARASHI
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

Related Concepts

Aspergillus Niger Infection
Biodermatin
Glutamate-Ammonia Ligase
RNA, Fungal
Aspergillus nidulans
Yeast Proteins
SGOT - Glutamate oxaloacetate transaminase
Biotinidase Deficiency
Cell-Free System
GLUD1

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