[Factors affecting survival prognosis of advanced gastric cancer and establishment of a nomogram predictive model].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
L ZhangQ Zhang

Abstract

To explore the factors affecting the survival of patients with advanced gastric cancer and establish a reliable predictive model of the patients' survival outcomes. We retrospectively collected the clinical data from patients with advanced gastric cancer treated in our department between January, 2015 and December, 2019. Univariate survival analysis was carried out using Kaplan-Meier method followed by multivariate Cox regression analysis to identify the factors associated with the survival outcomes of the patients. The R package was used to generate the survival rates, and a nomogram was established based on the results of multivariate analysis. The calibration curves and C-index were calculated to determine the predictive and discriminatory power of the model. The performance of the nomogram model for predicting the survival outcomes of the patients was evaluated using receiver- operating characteristic (ROC) curve analysis and decision curve analysis (DCA). Univariate analysis showed that the number of metastatic sites, the number of treatment lines received, disease control rate (DCR) and progression-free survival (PFS) time following first-line treatment, and surgical treatment in first-line treatment were significantly co...Continue Reading

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