Factors affecting the 2H to 18O dilution space ratio in infants

Pediatric Research
J C WellsW A Coward

Abstract

In the doubly labeled water (DLW) method, for measurement of energy expenditure in humans, calculation of carbon dioxide production rate is influenced by the ratio (R) of the dilution spaces of the tracer isotopes 2H and 18O. Recent publications have recommended use of a fixed value for R, using a mean population value (meanR) rather than individually derived experimental values. However, most of the data considered previously were derived from adults. Infants are characterized by rapid rates of energy deposition and high body water content, either of which could influence isotope kinetics. We have considered whether use of a fixed R value is suitable for DLW studies of infants, and whether the adult (meanR) value is appropriate. Data from 281 DLW measurements in healthy infants aged 6 wk to 12 mo were analyzed. Mean R of all measurements was 1.036 (SD 0.019), very similar to (meanR) values recommended for adults. We found analytical precision could account for almost all between-subject variation at a single time point. However, we also found relationships between R and age and weight gain, indicating that physiology does influence the space ratio. The effect of weight gain on R was negligible, but changes of (meanR) with age,...Continue Reading

References

Mar 1, 1979·The American Journal of Clinical Nutrition·H P Sheng, R A Huggins
Nov 1, 1985·Archives of Disease in Childhood·S B Roberts, A Lucas
May 1, 1982·The American Journal of Clinical Nutrition·S J FomonS E Nelson

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Citations

Oct 24, 1998·Nutrition·J C Wells
Aug 23, 2005·Archives of Disease in Childhood·J C K WellsT J Cole
Feb 28, 2001·The British Journal of Nutrition·J R SpeakmanV Legrand-Defretin
Jan 16, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ellen W Demerath, David A Fields
Mar 10, 2017·Isotopes in Environmental and Health Studies·Christian FabiansenJonathan C Wells
Nov 1, 2018·Journal of Veterinary Internal Medicine·Natalie C FinchJonathan Elliott
Oct 10, 2002·European Journal of Clinical Nutrition·P S W DaviesF J Accurso
Jan 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C K Wells, C G Victora
Jun 24, 2000·Annals of the New York Academy of Sciences·W W Koo
Mar 6, 2021·Cell Reports Medicine·John R SpeakmanUNKNOWN IAEA DLW database group

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