Factors affecting the adoption and use of gene expression profiling by oncologists in clinical practice

Personalized Medicine
Dhaval Patil, Amalia M Issa

Abstract

In this study, we evaluated the association between oncologists' perceptions of and attitudes toward one frequently used gene expression profiling assays, the Oncotype DX® and oncologists' intention to use this assay in making treatment recommendations for breast cancer patients. A nationally representative sample of breast cancer oncologists was surveyed using an adapted technology acceptance model. The survey response rate was 44.1%. The test characteristics `validity of the test' (p = 0.006) and 'use of Oncotype DX by fellow oncologists' (p = 0.0068) were significantly associated with use of the assay by oncologists. Oncologists' intention to use Oncotype DX increased consistently with their perceptions about its usefulness (β = 0.222). Insurance status of the patients was also significantly associated with physicians' use of Oncotype DX (p = 0.008). We report a novel application of an adapted technology acceptance model to understand the adoption of gene expression profiling by oncologists who treat breast cancer patients in making treatment recommendations.

References

Sep 17, 2004·Journal of Managed Care Pharmacy : JMCP·Sonja J Lewis, Burton I Orland
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jan 13, 2006·Archives of Internal Medicine·Esi Morgan DeWittFrederick Wolfe
Feb 7, 2008·Annals of Internal Medicine·Luigi MarchionniSteven N Goodman
Sep 24, 2008·American Journal of Surgery·Juhi AsadPaul I Tartter
Feb 11, 2009·Journal of Surgical Oncology·Leonard R HenryPeter W Soballe
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelly S LoKathy S Albain
Apr 24, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Shmuel H KlangJohn Hornberger
May 5, 2010·Nature Reviews. Clinical Oncology·Chungyeul Kim, Soonmyung Paik
Jan 5, 2011·Breast Cancer Research and Treatment·Foluso O AdemuyiwaSunil Badve
Sep 3, 2011·Journal of Evaluation in Clinical Practice·Yun-Chieh Lu, Ying-Chun Li
Apr 6, 2012·Journal of General Internal Medicine·Mira L KatzElectra D Paskett
Jan 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H A AzimC Swanton
Feb 9, 2013·Genetic Testing and Molecular Biomarkers·Christina G SelkirkPeter J Hulick
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Software Mentioned

SAS Analytics Pro
Oncotype DX
Qualtrics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Clinical Oncology
Michail Ignatiadis, Christos Sotiriou
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
C MarkopoulosH Gogas
© 2022 Meta ULC. All rights reserved