Feb 1, 1976

Factors affecting the binding of tricyclic tranquillizers and antidepressants to human serum albumin

The Journal of Pharmacy and Pharmacology
D Sharples

Abstract

The linear free energy-related model for structure activity relations developed by Hansch & Fujita (1964) has been used to correlate the binding of tricylic tranquillizers and antidepressants to human serum albumin (HSA) with hydrophobic and electronic parameters. The parameters chosen being the chromatographic parameter (Rm) and the affinity of charge transfer complex formation (kc). The relative importance of these factors has been assessed by linear and multiple linear regression analysis. Results show that the major factor in binding is electronic with only a minor contribution from the hydrophobic parameter.

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References

Mentioned in this Paper

Antipsychotic Effect
ALB
Albumin Human, USP
Human Serum Albumin [EPC]
Fluorescence Spectroscopy
Plasma Protein Binding Capacity
Charge transfer complex
Plasma Albumin
Regression Analysis
Antidepressant Measurement

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