PMID: 45124Jun 1, 1979

Factors affecting the bluetongue virus neutralizing antibody response and the reaction between virus and antibody

The Onderstepoort Journal of Veterinary Research
N T van der Walt


A study was made of different aspects of the bluetongue virus neutralizing antibody response and the reaction between the virus and antibody. Optimum neutralization was obtained in a 2mM Tris-HCl buffer, pH 9,0, at a temperature of 4 degrees C. The reaction of virus and antibody could be demonstrated by electron microscopy in the formation of clumps which were shown to be serotype specific. It was found that both IgM and IgG antibodies can neutralize the virus, but that IgM reached its maximum level sooner after infection than IgG.

Related Concepts

Antibodies, Viral
Antibody Formation
Antigen-Antibody Reactions
Bluetongue virus
Hydrogen-Ion Concentration
Electron Microscopy
Neutralization Tests

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