PMID: 9632582Jun 25, 1998Paper

Factors affecting the collagen binding capacity of Staphylococcus aureus

Infection and Immunity
A F GillaspyM S Smeltzer

Abstract

To determine whether the ability of Staphylococcus aureus to bind collagen involves an adhesin other than the collagen adhesin encoded by cna, we examined the collagen binding capacity (CBC) of 32 strains of S. aureus. With only two exceptions, a high CBC corresponded with the presence of cna. Both exceptions involved cna-positive strains with a low CBC. The first was a single strain (ACH5) that encoded but did not express cna. The second were the mucoid strains Smith diffuse and M, both of which encoded and expressed cna but bound only minimal amounts of collagen. Analysis of capsule mutants suggests that the reduced CBC observed in the mucoid strains was due to masking of the collagen adhesin on the cell surface and that this masking effect is restricted to heavily encapsulated strains. Differences in the CBC of the remaining cna-positive strains were correlated to variations in the level of cna transcription and were independent of the number of B domain repeats in the cna gene. In all cna-positive strains other than ACH5, cna transcription was temporally regulated, with cna mRNA levels being highest in cells taken from exponentially growing cultures and falling to almost undetectable levels as cultures entered the post-expo...Continue Reading

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Citations

Feb 18, 2003·Journal of Applied Microbiology·I Elgalai, H A Foster
Jan 5, 2005·Journal of Bacteriology·James E CassatMark S Smeltzer
Sep 24, 2005·Infection and Immunity·Türkan SakincSören G Gatermann
Nov 26, 2013·Future Microbiology·Sarah Elizabeth MaddocksRose Agnes Cooper
May 18, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Laurie Jones-JacksonMark S Smeltzer
Jul 18, 2003·Journal of Bacteriology·Kristen M SterbaMark S Smeltzer
Dec 24, 2002·Infection and Immunity·Jon S BlevinsMark S Smeltzer
Jan 18, 2002·Infection and Immunity·Thanh LuongChia Y Lee
May 5, 1999·FEMS Microbiology Letters·M C HudsonK P Frankenburg
Jun 24, 2003·Infection and Immunity·Karen E BeenkenMark S Smeltzer
Jan 2, 2004·Microbiology·Lindsey ShawSimon J Foster
Jul 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Niraj Procopio Evagrio GeorgeJulia M Ross
Sep 18, 2004·Journal of Bacteriology·Chi Hye ParkSi Myung Byun
Jul 27, 1999·Proceedings of the Association of American Physicians·B E Murray, G M Weinstock
Jan 18, 2002·Infection and Immunity·Jon S BlevinsMark S Smeltzer
Jul 23, 1999·Infection and Immunity·J L SnodgrassM S Smeltzer
Jul 23, 1999·Infection and Immunity·S J PeacockT J Foster
May 10, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R San-JuanF Chaves
Feb 2, 2021·Virulence·Gordon Y C CheungMichael Otto
Jun 6, 2017·Frontiers in Microbiology·Dafne Pérez-MontareloFernando Chaves

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