PMID: 6408568Apr 1, 1983Paper

Factors affecting the growth of head and neck squamous carcinoma cell lines

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
E VirolainenC J Krause

Abstract

Cell plating density influences the growth pattern of human squamous cell carcinoma (SCC) cell lines in culture. SCC lines were used to study factors responsible for these effects. Experiments in which the medium was changed daily or in which conditioned medium was used showed that the growth-supporting factors were not found in the media. However, when cells were plated in dishes in which the same cell line had been grown to confluence and removed by scraping, logarithmic growth began immediately. The effect was not seen on areas of the plate that had been covered with coverslips or in dishes where fibroblasts had been cultured. Antibodies to fibronectin, laminin, and a variety of epidermal cell antigens were used to determine the nature of the growth-stimulating substances remaining on the dish following cell removal. Results indicate that an extracellular matrix with similarities to basement membranes was present on the conditioned dishes.

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Citations

Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J LukerS S Prime
Mar 1, 1985·Journal of Surgical Oncology·H B GrossmanL Q Ren
May 29, 2003·The Journal of Biological Chemistry·Sichuan XiJennifer Rubin Grandis
Mar 1, 1990·The Journal of Pathology·S S PrimeC Scully
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J LukerS S Prime
Aug 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W J RichtsmeierK Sorge
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·R GrenmanH Joensuu
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·R GrenmanT Carey
Oct 1, 1986·The Journal of Urology·H B GrossmanB Cox
Apr 26, 2002·Oncogene·Paul L LeongJennifer Rubin Grandis

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