Factors affecting the incident juvenile bone tumors in an Austrian case-control study

Cancer Detection and Prevention
Rainer Frentzel-BeymeMartin Salzer

Abstract

This case-control study investigates etiologically important factors for juvenile osteosarcomas and possible reasons for the relative scarcity of their incidence in the population. Information on a variety of risk factors, psychosocial factors, and factors possibly occurring in early childhood was obtained by interviewing 88 patients (ages 8-25 years) with osteosarcoma, Ewing's sarcomas and other bone tumors, and three age- and sex-matched control groups (hospital, neighbour and family controls), and their mothers. For both sexes, children's diseases in their history, which increased the risk were measles (RR = 1.56, not significant) and mumps (RR = 1.81, 95% CI = 1.05-3.13), whereas clinically apparent chickenpox was associated with a significant decrease for bone tumors (RR = 0.46, 95% CI = 0.26-0.8). Dermal and respiratory allergies (without hay fever) were also inversely associated with bone tumors. Breast feeding for longer than 2 months was associated with low risk for bone tumors for boys, whereas for girls, paternal age was a risk factor; remaining stable in a multivariate model (RR = 2.36, 95% CI = 0.90-6.21). A change in the presence of an emotionally significant person or changes of residence were risk factors both i...Continue Reading

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Citations

Feb 22, 2011·Cancer Causes & Control : CCC·Ramandeep S AroraJillian M Birch
Jun 29, 2012·BMC Cancer·Richard J Q McNallyRichard G Feltbower
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Richard M MartinGeorge Davey Smith
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Feb 21, 2009·IEEE Transactions on Pattern Analysis and Machine Intelligence·Michael G Ross, Leslie Pack Kaelbling
Feb 9, 2021·Frontiers in Oncology·Manuela MarronWolfgang Ahrens

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