Factors affecting the loss of carbon monoxide from stored blood samples

Journal of Analytical Toxicology
D H ChaceN T Lappas

Abstract

The loss of carbon monoxide (CO) from whole blood or hemolysates has been investigated. Blood samples were exposed to the atmosphere or to a limited volume of air for various storage periods at three temperatures. The initial hemoglobin (Hb) concentration and the percent carboxyhemoglobin (%COHb) saturation were varied in separate experiments. In addition, the effect of repeated exposure of blood to air was evaluated. The %COHb saturation decreased from 80 to 50% following storage of a 1-mL blood sample with 49 mL of air in a sealed container at room temperature for 45 hr. Greater decreases in the %COHb saturation were observed in samples which were exposed to the atmosphere. Lesser, but significant, losses occurred when samples were stored in a refrigerator or freezer. The concentration of Hb in the samples as well as the initial %COHb saturation were found to influence the decrease in the %COHb saturation.

Citations

Aug 23, 2001·Forensic Science International : Synergy·Y SetoK Tsuge
Feb 15, 2008·The American Journal of Emergency Medicine·Neil B Hampson
Jan 19, 2010·Paediatric and Perinatal Epidemiology·Carole B RudraJianbo Yu
Oct 5, 2006·Journal of Forensic Sciences·Hendrik J VremanH Ronald Zielke
Dec 4, 2019·Forensic Science International : Synergy·Stefania Oliverio, Vincent Varlet

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