Factors affecting the release of nifedipine from a swellable elementary osmotic pump

Drug Delivery
A NokhodchiParinaz Ahmad Rashidi

Abstract

Oral osmotic devices including an elementary osmotic pump (EOP) are efficient systems for the delivery of drugs with high/moderately water-solubility. In this study we designed a new type of EOP for the efficient delivery of poorly water-soluble and practically insoluble drugs. In this system, called swellable elementary osmotic pump (SEOP), drug is released from the delivery orifice in the form of a very fine dispersion of drug in gel which is ready for dissolution and absorption. Factors affecting the release of drug from the SEOP containing a poorly water-soluble drug, nifedipine, were explored extensively. To this end, effect of swelling and wetting agents, orifice size, concentration of osmotic agent, and hydrophobic plasticizer were investigated. Interestingly, in the absence or low concentration of a hydrophobic plasticizer (caster oil), the osmotic devices did not retain their integrity in dissolution media. Caster oil in concentration of > 1% was necessary for tablets to retain their integrity during dissolution process. A zero-order release kinetics for nifedipine was achieved following the effective optimization of the concentrations of swelling agent, osmotic agent, wetting agent, and also size of orifice and membra...Continue Reading

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Citations

Oct 20, 2010·International Journal of Molecular Sciences·Heidi M MansourPatrick P Deluca
Nov 8, 2008·Drug Development and Industrial Pharmacy·Vincent MalaterreRobert Gurny
Jul 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Vincent MalaterreRobert Gurny
Sep 16, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei-Li LaracuenteKevin J McHugh

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