Factors affecting the severity of central centrifugal cicatricial alopecia

International Journal of Dermatology
Poonkiat SuchonwanitA McMichael

Abstract

Central centrifugal cicatricial alopecia (CCCA) is a type of scarring hair loss primarily seen in African-American women. The risk factors that affect the severity of disease remain unclear. This study was designed to elucidate risk factors that may be associated with severity of CCCA. A cross-sectional survey study was conducted. Women with biopsy-confirmed CCCA responded to a questionnaire and were grouped according to a photographic scale of central scalp alopecia. The severity of disease was considered: grade 1 and 2 disease was interpreted as early-stage CCCA, and grade 3-5 disease was interpreted as advanced-stage CCCA. Data from the questionnaire were compared with levels of severity to determine the strength of associations with severity of disease. A total of 38 women with biopsy-confirmed CCCA were recruited to participate in this study. Early-stage CCCA was seen in 22 subjects (57.9%), and advanced-stage CCCA was noted in 16 subjects (42.1%). The average duration of hair loss was 5.7 years in early-stage disease and 10.1 years in advanced-stage disease. There was a positive correlation between duration of hair loss and degree of hair loss (Spearman's correlation 0.471, P = 0.003). This study reports on data sourced f...Continue Reading

References

Jun 1, 1994·Archives of Dermatology·L C SperlingK Friedman
Jan 25, 2002·Journal of the American Academy of Dermatology·Nanette B SilverbergVincent A DeLeo
Jun 6, 2003·Journal of the American Academy of Dermatology·Amy J McMichael
Apr 29, 2004·Dermatologic Therapy·Valerie D CallenderGeorge F Cohen
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison
Jun 8, 2007·The British Journal of Dermatology·N P KhumaloR Ehrlich
Aug 30, 2007·The British Journal of Dermatology·N P KhumaloR Ehrlich
Oct 9, 2007·International Journal of Dermatology·Beatrice Amunga Etemesi
Aug 22, 2008·Dermatologic Therapy·E A OlsenD A Whiting
Aug 22, 2008·Dermatologic Therapy·David A Whiting, Elise A Olsen
Mar 19, 2009·Journal of the American Academy of Dermatology·Raechele Cochran Gathers, Henry W Lim
Dec 23, 2009·Archives of Dermatology·Paradi Mirmirani, Pratima Karnik
Nov 16, 2010·Journal of the American Academy of Dermatology·Elise A OlsenWilma Bergfeld
Feb 5, 2013·Journal of the American Academy of Dermatology·Barry LadizinskiElise A Olsen
Feb 1, 2014·Journal of the American Academy of Dermatology·Ncoza C DlovaEli Sprecher

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Citations

Feb 15, 2019·The New England Journal of Medicine·Liron MalkiEli Sprecher
May 20, 2020·Clinical, Cosmetic and Investigational Dermatology·Kanchana Leerunyakul, Poonkiat Suchonwanit
Apr 2, 2021·Drug Design, Development and Therapy·Thipprapai MahasaksiriPoonkiat Suchonwanit
Apr 30, 2021·Drug Design, Development and Therapy·Silada KanokrungseeKumutnart Chanprapaph
May 20, 2021·Clinical Interventions in Aging·Kumutnart ChanprapaphPoonkiat Suchonwanit
Jun 1, 2021·Dermatologic Clinics·Christina N LawsonValerie D Callender
Jul 24, 2021·Patient Preference and Adherence·Kunlawat Thadanipon, Poonkiat Suchonwanit
Aug 6, 2021·ImmunoTargets and Therapy·Poonkiat SuchonwanitCherrin Pomsoong

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