Factors affecting the success of endoscopic treatment of vesicoureteral reflux and comparison of two dextranomer based bulking agents: does bulking substance matter?

Journal of Pediatric Urology
Hasan Serkan DoganSerdar Tekgul

Abstract

Among the interventional treatment modalities for vesicoureteral reflux (VUR), endoscopic subureteric injection seems to be the least invasive method with acceptable outcomes when applied in appropriate patients. The aim of the presented study is to investigate the parameters which may affect the outcomes of endoscopic injection and to compare the efficacy of two different bulking agents both composed of dextranomer-hyaluronic acid copolymer. The data of patients who underwent endoscopic VUR treatment between 2003 and 2012 were retrospectively reviewed. Patients with history of previous open antireflux surgery, more than one failed endoscopic treatment for reflux, VUR caused by posterior urethral valve, duplex system and overt spinal dysraphism were excluded. Surgical technique was the classical STING method. One of the two dextranomer-hyaluronic acid copolymer agents was used (Deflux in 109 and Dexell in 131 patients). Both agents were composed of similar amounts of hyaluronic acid gel (15 mg in Deflux versus 17 mg in Dexell) but different sized dextranomer microspheres (80-250 μm in Deflux and 80-120 μm in Dexell). During the follow-up, ultrasonography was performed with 3-month interval, antibiotic prophylaxis was continued ...Continue Reading

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Citations

Oct 28, 2016·Journal of Endourology Case Reports·Jack CrozierDavid Clarke
Jun 11, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Ciro EspositoFrancois Varlet
Apr 20, 2021·Frontiers in Pediatrics·Göran LäckgrenAndrew J Kirsch
Sep 21, 2017·Journal of Pediatric Surgery·Ling LeungKenneth Kak Yuen Wong

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