PMID: 7470434Jan 1, 1981

Factors affecting the voluntary intake of food by sheep. 3. The effect of intravenous infusions of gastrin, cholecystokinin and secretin on motility of the reticulo-rumen and intake

The British Journal of Nutrition
W L Grovum


1. Sheep given ground and pelleted lucerne hay (Medicago sativa) ad lib. were infused intravenously with pentagastrin, secretin, cholecystokinin (CCK) and its analogues to assess their effects on motility of the reticulo-rumen and on food intake. In the latter experiments the animals were deprived of their diet for periods of up to 6 h to induce hunger and the infusions were made before and during 3-10 min periods of feeding. 2. Pentagastrin, and analogue of gastrin, depressed intake by 35-50% (P less than 0.05) when it was infused at 9 microgram/kg per h during 30 min of feeding. The threshold may however be below 1 microgram/kg per h as this dose decreased intake of 12-17%. The frequency of reticular contractions decreased by 13, 35, 39 and 44% when 1, 3, 9, and 27 microgram pentagastrin/kg per h respectively was infused (P less than 0.025). 3. Secretin depressed food intake 38% after 30 min (P less than 0.025) when 8 Clinical Units (CU)/kg per h was infused but the threshold could be less than this dose since 0.5 CU/kg per h depressed intake by 12%. Contraction amplitude but not frequency decreased at 8 CU/kg per h. 4. CCK produced a 39% decrease in intake during the first 10 min of feeding (P less than 0.05) and the thresho...Continue Reading


May 13, 1976·The New England Journal of Medicine·P L RayfordJ C Thompson
Sep 1, 1978·Gut·O B Schaffalitzky de Muckadell, J Fahrenkrug
Jan 1, 1979·Annual Review of Physiology·M I Grossman
Jul 30, 1979·Life Sciences·A J KastinD H Coy
Oct 1, 1979·Canadian Journal of Physiology and Pharmacology·G H Anderson
Jun 19, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Oct 1, 1975·Journal of Animal Science·G W Horn, T L Huber
Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·K Mueller, S Hsiao
May 1, 1979·The Proceedings of the Nutrition Society·I E Liener
Jan 15, 1979·Life Sciences·S I Said, J C Porter
May 15, 1979·Experientia·G J Dockray
Nov 8, 1979·Nature·J GibbsS P Maddison
Aug 1, 1979·Physiology & Behavior·S IshibashiS Shibata
Jul 1, 1979·Physiology & Behavior·D A VanderweeleD Novin
Nov 12, 1979·Life Sciences·V MuttK Tatemoto
Dec 1, 1978·Physiology & Behavior·N Snapir, Z Glick
May 19, 1978·Science·C B NemeroffA J Prange
Aug 1, 1977·Australian Veterinary Journal·D A Titchen, N Anderson
Dec 1, 1977·Physiology & Behavior·S M AnikaK A Houpt
Oct 1, 1977·Physiology & Behavior·J R Martin, D Novin
Jul 1, 1978·Physiology & Behavior·S Mineka, C T Snowdon
Nov 1, 1978·Behavioral Biology·J A Deutsch, M F Gonzalez
Nov 1, 1978·Behavioral Biology·J A DeutschL H Greenberg
Jan 5, 1979·Science·E Straus, R S Yalow
Jan 1, 1976·The American Journal of Physiology·J GibbsP R McHugh
Oct 1, 1976·Canadian Journal of Physiology and Pharmacology·M Rezek
Jan 1, 1977·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellJ J Holst
Jun 24, 1976·Nature·R A Sturdevant, H Goetz
May 1, 1976·Journal of Comparative and Physiological Psychology·J J SternJ Kruper
Sep 1, 1976·Physiology & Behavior·L L BernsteinJ C Zimmerman
Oct 1, 1976·Australian Journal of Biological Sciences·M Pass, T Heath
Jul 1, 1975·The Journal of Physiology·L M McLEAY, D A Titchen
Apr 1, 1975·Physiology & Behavior·J PankseepM Ritter
Sep 1, 1975·Journal of Comparative and Physiological Psychology·J AntinG P Smith
Sep 17, 1975·Psychopharmacologia·M Rezek, D Novin
Sep 15, 1973·Lancet·A G Johnson, S J McDermott
Oct 13, 1973·Lancet·R F HarveyA E Read
Oct 1, 1974·The American Journal of Digestive Diseases·N VaysseA Ribet
Jul 1, 1973·Journal of Animal Science·L A Bruce, T L Huber
Sep 1, 1973·Journal of Comparative and Physiological Psychology·J GibbsG P Smith
Jan 1, 1973·Digestion·H T Debas, M I Grossman
Mar 1, 1974·The American Journal of Digestive Diseases·J A LevantJ I Isenberg
Feb 1, 1970·The American Journal of Digestive Diseases·M A OndettiJ T Sheehan
Oct 1, 1970·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·T Heath
Dec 1, 1969·The American Journal of Physiology·K SugawaraE R Woodward
Oct 1, 1968·The American Journal of Physiology·L R Johnson, M I Grossman
Oct 1, 1968·British Journal of Pharmacology·G BertacciniM Impicciatore


Jul 1, 1985·The Proceedings of the Nutrition Society·T R Houpt
Dec 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·Y Ruckebusch
May 22, 1998·Journal of Dairy Science·R M Bruckmaier, J W Blum
Jan 1, 1989·Nutrition Research Reviews·J J Parkins, P H Holmes
Aug 1, 1991·Archiv für Tierernährung·U Ranft, A Hennig
Jan 1, 1985·Annals of the New York Academy of Sciences·J E MorleyJ J Hughes
Jul 1, 1984·Zentralblatt für Veterinärmedizin. Reihe A·Y Ruckebusch, M Pairet
Jun 7, 2014·Frontiers in Endocrinology·Li Zhang, Billy Kwok Chong Chow
May 27, 2010·Journal of Endocrinological Investigation·D H St-Pierre, F Broglio
May 1, 1992·The Proceedings of the Nutrition Society·D V Rayner
Mar 9, 2018·The Journal of Experimental Biology·Katharina BraunMartin Klingenspor
Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie Yuen Yee ChengBilly Kwok Chong Chow
Mar 1, 2012·Asian-Australasian Journal of Animal Sciences·Tran Van ThangGo Ogura

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