PMID: 9523534Apr 2, 1998Paper

Factors affecting virus photoinactivation by a series of phenothiazine dyes

Photochemistry and Photobiology
Stephen J WagnerL Cincotta

Abstract

A series of four phenothiazine dyes, including methylene blue (MB), were previously tested for their ability to photoinactivate viruses in red cell suspensions. One of the dyes, 1,9-dimethyl-3-dimethylamino-7-dimethylaminophenothiazine (1,9-dimethylmethylene blue), exhibited good intracellular and extracellular virucidal activity for several RNA and DNA viruses under conditions that minimally affected red cell properties. In order to understand why the virucidal specificity of 1,9-dimethylmethylene blue was greater than other phenothiazines tested, the physical and chemical properties of the dye were compared to three other closely related analogues (MB, 1,9-dimethyl-3-diethylamino-7-dibutylaminophenothiazine [compound 4-140], 1,9-dimethyl-3-dimethylamino-7-diethylaminophenothiazine [compound 6-136]). All compounds required light and oxygen for virucidal activity and had relatively high singlet oxygen yields (> 0.5), but 1,9-dimethylmethylene blue had a singlet oxygen yield approximately 50% greater than that of MB. In addition, the hydrophobicity/hydophilicity of the compounds varied, with the partition coefficients (2-octanol : water) ranging from 0.11 for MB to 3560 for compound 4-140. The dyes had the following affinities f...Continue Reading

Citations

Apr 16, 2013·Lasers in Medical Science·Carlos de Paula EduardoJan Tunér
Dec 19, 2000·International Journal of Antimicrobial Agents·M Wainwright
Aug 28, 1999·Bioorganic & Medicinal Chemistry Letters·T Mohammad, H Morrison
Aug 6, 2000·British Journal of Haematology·D Pamphilon
Nov 3, 2011·Photochemistry and Photobiology·Mark WainwrightEhsaneh Lotfipour
May 16, 2012·Photochemistry and Photobiology·Xiaoying LiuYongming Zhu
Dec 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jie ChenPeter M Rentzepis
Apr 20, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Catrina G Pheeney, Jacqueline K Barton
Dec 27, 2011·Toxicology and Applied Pharmacology·Anél PetzerJacobus P Petzer
Aug 26, 2011·Photodiagnosis and Photodynamic Therapy·Mark Wainwright
Aug 26, 2011·Photodiagnosis and Photodynamic Therapy·Mark Wainwright, Mauricio S Baptista
Mar 17, 2010·Journal of Photochemistry and Photobiology. B, Biology·Mark WainwrightCiara Loughran
Jan 12, 2010·International Journal of Antimicrobial Agents·Mark WainwrightNicola Dempster
May 13, 2009·Biochemical Pharmacology·Murat OzGeorge A Petroianu
Jun 9, 2005·Tropical Medicine & International Health : TM & IH·Mark Wainwright, Leonard Amaral
Feb 28, 2014·Photochemistry and Photobiology·Isabel O L BacellarMauricio S Baptista
Sep 19, 2006·Journal of Photochemistry and Photobiology. B, Biology·Mark WainwrightWolfram H Walker
Aug 29, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Raymond P GoodrichJerard Seghatchian
Sep 1, 2005·Photodiagnosis and Photodynamic Therapy·João Paulo TardivoMauricio S Baptista
Dec 1, 2005·Photodiagnosis and Photodynamic Therapy·Mark Wainwright

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