PMID: 6989888Jan 1, 1980Paper

Factors altering the secretion of LHRH from superfused fragments of rat hypothalamus

Journal of Endocrinological Investigation
V D RamirezD Hartter

Abstract

This paper deals with the effect of temperature (t degrees), ions, prostaglandin (PGE2) and testosterone on the rate of release of LHRH from the superfused medial basal hypothalamus (MBH) of normal or castrated male rats in an effort to further validate the biological properties of this preparation. LHRH in the perfusate is nondetectable when the MBH is at 0 C, warming to 37 C produces a sharp rise in LHRH and then stabilization at a level at least threefold the one calculated for the 0 C experiment. Basal release rate of LHRH is t degrees and calcium dependent, as is the stimulatory action of potassium. Infusion of high K+ induces approximately a fivefold increase in the release rate of LHRH and stays at this high level for as long as the infusion lasts (50 min). LHRH stimulation by PGE2 (pulse) proceeds in the absence of external calcium, and the effect lasts longer than the potassium (pulse) action. Surprisingly, MBHs from long-ter castrated males (60-90 days) release less LHRH per minute than intact male MBHs during the steady state phase of LHRH secretion; testosterone propionate (TP, 200 microgram/100 g BW x 3 days) increases significantly the rate of release in castrate rats and is not related to the amount of LHRH assay...Continue Reading

References

Jul 1, 1978·Journal of Endocrinological Investigation·H WagnerR E Lang
May 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·E Gallardo, V D Ramirez
Jan 1, 1976·Neuroendocrinology·S H Shin, C J Howitt
Jan 1, 1975·Neuroendocrinology·J A MoguilevskyM R Faigon
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·S H Shin, C J Howitt
Jun 1, 1974·The Journal of Physiology·M W BradburyM T Jones
Nov 1, 1972·Biochemical and Biophysical Research Communications·N G JohanssonC Y Bowers

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Citations

Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S KaranthS M McCann
Jul 1, 1994·Trends in Endocrinology and Metabolism : TEM·S S StojilkovicK J Catt
Nov 17, 2006·Reproduction in Domestic Animals = Zuchthygiene·S P S GhumanH Dobson
Apr 1, 1991·Journal of Neuroendocrinology·S Wibullaksanakul, D J Handelsman
Jan 1, 1989·Annals of the New York Academy of Sciences·S R OjedaJ Capdevila

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