Factors associated with albumin loss in post-dilution hemodiafiltration and nutritional consequences

The International Journal of Artificial Organs
Anne FournierJean-Michel Halimi

Abstract

Hemodiafiltration is currently one of the most effective techniques of extra-renal purification but results in an increase of albumin loss in dialysate. We aimed to determine the factors associated with albumin loss during post-dilution hemodiafiltration, compare an "automatic" mode of infusate flow control versus a "manual" control, and assess the potential nutritional impact. This prospective observational study included all hemodialysis patients in our institution who underwent post-dilution hemodiafiltration 3 times a week on a Fresenius 5008 for at least 2 months. At each session, albumin content was measured in a representative effluent dialysate volume. The automatic mode of the Fresenius 5008 was used for automatic infusate flow control. In all, 18 patients (mean age 60.7 ± 15 years) underwent 85 post-dilution hemodiafiltration sessions. The mean albumin loss was 3134 ± 2450 mg/session. Albumin loss was significantly affected by infusate flow, infusate volume, transmembrane pressure and ultrafiltration volume. The loss was greater with Toraysulfone and FX 1000 membranes rather than FX 80 or FX 100 membranes. With AutoSub rather than manual control, infusate flow was greater (P<.001), transmembrane pressure was higher (P...Continue Reading

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Citations

Apr 30, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kojiro NagaiJun Minakuchi
May 8, 2018·Nature Reviews. Nephrology·Claudio Ronco, William R Clark
Oct 4, 2018·Artificial Organs·Michael HulkoBernd Krause
Oct 30, 2019·BMC Nephrology·Charles CuvelierJean-Michel Pochet
Nov 7, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maaike K van GelderKarin G F Gerritsen
Jun 3, 2017·The International Journal of Artificial Organs·Carina ZweigartBernd Krause
Mar 20, 2020·Nutrients·Giorgina Barbara PiccoliAdamasco Cupisti

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Software Mentioned

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