Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance

Blood Cancer Journal
J M PiotB Bouvard

Abstract

Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients. All patients had spinal radiographs and bone mineral density measurement in addition to gammopathy assessment. At least one prevalent non-traumatic vertebral fracture was discovered in 18.4% patients and equally distributed between men and women. Fractured patients were older, had a lower bone density and had also more frequently a lambda light chain isotype. Compared with patients with κ light chain, the odds ratio of being fractured for patients with λ light chain was 4.32 (95% confidence interval 1.80-11.16; P=0.002). These results suggest a high prevalence of non-traumatic vertebral fractures in MGUS associated with lambda light chain isotype and not only explained by low bone density.

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C CooperL J Melton
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·E A MyattF J Stevens
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K GenantM C Nevitt
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T W O'NeillA J Silman
Aug 18, 1997·The American Journal of Medicine·P D Ross
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L J MeltonB L Riggs
Feb 15, 2001·JAMA : the Journal of the American Medical Association·R LindsayE Seeman
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Mar 29, 2002·British Journal of Haematology·Sophie RouxXavier Mariette
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonRobert A Kyle
Aug 24, 2006·British Journal of Haematology·Henrik GregersenMette Nørgaard
Aug 30, 2006·British Journal of Haematology·Robert A Kyle, S Vincent Rajkumar
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Vaishali Sanchorawala
Jun 18, 2011·American Journal of Hematology·Angela Dispenzieri
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evangelos TerposG David Roodman
Oct 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew T Drake

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Citations

Feb 26, 2016·Journal of Cellular Physiology·Rebecca Silbermann, Garson David Roodman
May 21, 2020·International Journal of Molecular Sciences·Agostino GaudioPietro Castellino
Dec 7, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H CheK Briot
Jan 25, 2020·Journal of Bone and Mineral Metabolism·Guillermina OrdunaAdolfo Díez-Pérez
Aug 23, 2018·Frontiers in Endocrinology·Barry G Hansford, Rebecca Silbermann
Apr 13, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Pierre-Emmanuel CailleauxKarine Briot
Aug 28, 2021·International Journal of Molecular Sciences·Massimo De MartinisSebastiano Gangemi
Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat

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Methods Mentioned

BETA
electrophoresis
X-ray
biopsy

Software Mentioned

SPSS
Statistical Package for the Social Sciences ( SPSS

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