Aug 22, 2017

Factors Associated with Anticoagulation Delay Following New-Onset Atrial Fibrillation

The American Journal of Cardiology
Shaan KhurshidSteven A Lubitz


Oral anticoagulation (OAC) is effective yet reportedly underutilized for stroke prevention in atrial fibrillation (AF). Factors associated with delayed OAC after incident AF are unknown. Using a large electronic medical record, we identified incident episodes of AF diagnosed in 2006 to 2014 using a validated algorithm. Among patients with a Congestive heart failure, Hypertension, Age, Diabetes, and Stroke (CHADS2) score ≥1 started on OAC within 1 year, we examined baseline characteristics at AF diagnosis and their association with time to OAC using multivariable Cox proportional hazards modeling. Of 4,388 patients with incident AF and CHADS2 score ≥1 who were started on OAC within 1 year, the mean age was 72.6, and 41% were women. Median time to OAC was 5 days (interquartile range 1 to 43), and most patients received warfarin (86.3%). Among patients without prevalent stroke, 98 strokes (2.2% of the sample) occurred between AF diagnosis and OAC initiation. In multivariable analyses, several factors were associated with delayed OAC including female gender (hazard ratio [HR] 1.08, 95% confidence interval [CI] 1.01 to 1.15), absence of hypertension (HR 1.15, 95% CI 1.03 to 1.27), previous fall (HR 1.53, 95% CI 1.08 to 2.17), and ch...Continue Reading

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Mentioned in this Paper

Prescription Procedure
Electronic Health Records
Chronic Kidney Insufficiency
Transcription Initiation
Negative Regulation of Coagulation
Decreased Coagulation Activity [PE]
Atrial Fibrillation
Acute Cerebrovascular Accidents
Cerebrovascular Accident

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