Factors associated with bone metabolism in acromegalic patients: hypogonadism and female gender

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
N B Tütüncü, T Erbaş

Abstract

The purpose of the study was to determine the factors associated with bone metabolism in acromegalic patients. Thirty three patients with acromegaly who had been followed on a regular basis in the endocrinology clinic were enrolled for the study. Among the factors acting upon bone metabolism, age, gender, body mass index (BMI), duration and activity of the disease, length of remission, treatment modalities and functional status of the pituitary were evaluated. Their influences on the determinants of bone remodelling and bone mineral density (BMD) were tried to be elucidated. The median age of the 33 acromegalics (19 females, 14 males) was 39.73 +/- 10.1 years. Twenty-three patients (9 males and 14 females) were eugonadal. Ten patients had been diagnosed with history of at least one year of untreated hypogonadism (5 males and 5 females; for 1 - 10 years). The BMD values of the lumbar vertebrae, the femur and the radius were correlated with each other. Patients were grouped according to their T-scores as decreased, normal, and increased BMD. Groups were similar with regard to age, BMI, gender, duration of disease, and remission, GH, IGF-1, IGFBP-3 levels, markers of bone turnover. Presence of hypogonadism and duration of hypogona...Continue Reading

Citations

Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Mar 29, 2008·Pituitary·Laurence Katznelson
May 5, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yongbo ZhaoZhou Fei
Jun 5, 2007·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Darko KastelanMirko Korsic
Oct 9, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A R HongC S Shin
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Gherardo MazziottiAndrea Giustina
Sep 17, 2021·Archives of Osteoporosis·Madalina Cristina SorohanCatalina Poiana

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