Factors associated with cancer incidence and with all-cause mortality after cancer diagnosis among human immunodeficiency virus-infected persons during the combination antiretroviral therapy era

Open Forum Infectious Diseases
Pragna PatelRichard M Novak

Abstract

Little is known about survival and factors associated with mortality after cancer diagnosis among persons infected with human immunodeficiency virus (HIV). Using Poisson regression, we analyzed incidence rates of acquired immune deficiency syndrome (AIDS)-defining cancers (ADC), non-AIDS-defining infection-related cancers (NADCI), and non-AIDS-defining noninfection-related cancers (NADCNI) among HIV Outpatient Study participants seen at least twice from 1996-2010. All-cause mortality within each cancer category and by calendar period (1996-2000, 2001-2005, 2006-2010) were examined using Kaplan-Meier survival methods and log-rank tests. We identified risk factors for all-cause mortality using multivariable Cox proportional hazard models. Among 8350 patients, 627 were diagnosed with 664 cancers. Over the 3 time periods, the age- and sex-adjusted incidence rates for ADC and NADCNI declined (both P < .001) and for NADCI did not change (P = .13). Five-year survival differed by cancer category (ADC, 54.5%; NADCI, 65.8%; NADCNI, 65.9%; P = .018), as did median CD4 cell count (107, 241, and 420 cells/mm(3); P < .001) and median log10 viral load (4.1, 2.3, and 2.0 copies/mL; P < .001) at cancer diagnosis, respectively. Factors independe...Continue Reading

References

Apr 2, 1998·The New England Journal of Medicine·J N MartinD H Kedes
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·R M PhelpsUNKNOWN HER Study Group
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Henry K TamRoger Detels
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Jun 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy A HessolUNKNOWN WIHS Collaborative Study Group
Jul 13, 2004·Journal of Hepatology·Anaïs Vallet-Pichard, Stanislas Pol
Mar 17, 2005·Journal of the National Cancer Institute·Gary M CliffordUNKNOWN Swiss HIV Cohort
Apr 19, 2005·European Journal of Internal Medicine·Javier MurillasConcepcion Villalonga
Jan 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy F CrumUNKNOWN Triservice AIDS Clinical Consortium
Aug 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Frank J PalellaUNKNOWN HIV Outpatient Study Investigators
Aug 31, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Linda A Colville, Andy H Lee
Apr 26, 2008·International Journal of Cancer. Journal International Du Cancer·Eric A EngelsJames J Goedert
May 14, 2008·Current HIV Research·George PanosMatthew E Falagas
May 21, 2008·Annals of Internal Medicine·Pragna PatelUNKNOWN Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators
Jul 3, 2008·JAMA : the Journal of the American Medical Association·Krishnan BhaskaranUNKNOWN CASCADE Collaboration
Oct 4, 2008·AIDS·Antonella d'Arminio MonforteUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
Dec 25, 2008·Current Opinion in Oncology·Fabrice Bonnet, Geneviève Chêne
Feb 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fabrice BonnetUNKNOWN Mortavic Study Group
Sep 11, 2009·AIDS·Michael J SilverbergDonald I Abrams
Sep 23, 2009·AIDS·UNKNOWN HIV-CAUSAL CollaborationMiguel A Hernán
Sep 23, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meredith S ShielsCharles Poole
Oct 13, 2009·The Lancet Oncology·Marguerite GuiguetUNKNOWN Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort
Mar 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M C F ProsperiUNKNOWN Icona Foundation Study Group
May 6, 2010·Journal of the National Cancer Institute·Sara LodiUNKNOWN CASCADE Collaboration
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anouk KesselringFerdinand Wit
Apr 12, 2012·International Journal of Epidemiology·UNKNOWN Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoordGeneviève Chêne
Jun 6, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth L YanikJoseph J Eron

❮ Previous
Next ❯

Citations

Nov 12, 2015·Current Opinion in Infectious Diseases·Paul Collini, Alison Morris
May 16, 2018·Infectious Agents and Cancer·Valeria I FinkUNKNOWN CCASAnet
Aug 14, 2019·AIDS Research and Human Retroviruses·Jessica L CastilhoTimothy R Sterling
Oct 18, 2016·Current Opinion in HIV and AIDS·Meredith S Shiels, Eric A Engels
Mar 7, 2021·Journal of Clinical Medicine·Julia Portilla-TamaritJoaquín Portilla
Mar 21, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Pablyanne Tereza Louzada GuedesHélder Antônio Rebelo Pontes
Oct 6, 2015·Annals of Internal Medicine·Michael J SilverbergUNKNOWN North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AID

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.