Factors associated with case fatality of human H5N1 virus infections in Indonesia: a case series

Lancet
I Nyoman KandunToni Wandra

Abstract

Indonesia has had the most human cases of highly pathogenic avian influenza A (H5N1) and one of the highest case-fatality rates worldwide. We described the factors associated with H5N1 case-fatality in Indonesia. Between June, 2005, and February, 2008, there were 127 confirmed H5N1 infections. Investigation teams were deployed to investigate and manage each confirmed case; they obtained epidemiological and clinical data from case-investigation reports when possible and through interviews with patients, family members, and key individuals. Of the 127 patients with confirmed H5N1 infections, 103 (81%) died. Median time to hospitalisation was 6 days (range 1-16). Of the 122 hospitalised patients for whom data were available, 121 (99%) had fever, 107 (88%) cough, and 103 (84%) dyspnoea on reaching hospital. However, for the first 2 days after onset, most had non-specific symptoms; only 31 had both fever and cough, and nine had fever and dyspnoea. Median time from onset to oseltamivir treatment was 7 days (range 0-21 days); treatment started within 2 days for one patient who survived, four (36.4%) of 11 receiving treatment within 2-4 days survived, six (37.5%) of 16 receiving treatment within 5-6 days survived, and ten (18.5%) of 44...Continue Reading

References

Feb 27, 2004·The New England Journal of Medicine·Tinh Hien TranUNKNOWN World Health Organization International Avian Influenza Investigative Team
Jan 26, 2005·The New England Journal of Medicine·Kumnuan UngchusakSupamit Chunsutthiwat
Sep 30, 2005·The New England Journal of Medicine·Anne Moscona
Oct 11, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Menno D de Jong, Tran Tinh Hien
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Nov 25, 2006·The New England Journal of Medicine·Robert G Webster, Elena A Govorkova
Nov 25, 2006·The New England Journal of Medicine·Ahmet Faik OnerMehmet Ceyhan
Mar 1, 2007·Emerging Infectious Diseases·Pham Ngoc DinhUNKNOWN World Health Organization/Global Outbreak Alert and Response Network Avian Influenza Investigation Team in Vietnam
May 15, 2007·Avian Diseases·David L SuarezElizabeth Ellis
Jul 13, 2007·The Journal of Infectious Diseases·Endang R SedyaningsihTriono Soendoro
Sep 25, 2007·Nature Medicine·Juergen PipperLukas Novak

❮ Previous
Next ❯

Citations

Apr 6, 2012·Current Infectious Disease Reports·Lucia MarzorattiSandra B Figueroa
Mar 25, 2011·Environmental Health and Preventive Medicine·Hiroyuki FuruyaTetsu Watanabe
Jan 18, 2013·Virologica Sinica·Jingchuan YinYing Zhu
Nov 1, 2013·The Journal of Microbiology·Byeong-Jae LeeYoung Ki Choi
Jun 6, 2013·Virus Research·Guus F Rimmelzwaan, Jacqueline M Katz
Oct 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tjandra Y AditamaI Nyoman Kandun
Jul 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janice K LouieTimothy M Uyeki
Mar 20, 2010·The Journal of Antimicrobial Chemotherapy·James R Smith
Jun 15, 2010·BMC Infectious Diseases·Annette FoxHeiman Wertheim
Jun 7, 2013·BMC Public Health·Karen Humphries-WaaRichard Coker
Jun 26, 2009·PLoS Medicine·Nicholas J WhiteTimothy M Uyeki
Jan 13, 2012·PloS One·Tjandra Y AditamaI Nyoman Kandun
Oct 30, 2010·Emerging Infectious Diseases·Ji ZhangZhan Li
Jan 19, 2012·International Journal of Medical Sciences·Ilyse DarwishW Conrad Liles
Feb 4, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chen WangLanjuan Li
Jan 7, 2014·Bulletin of the World Health Organization·Stephanie WilliamsUNKNOWN Case-based Surveillance Evaluation Group
Mar 19, 2013·Virus Research·Laurence JossetMichael G Katze
Jul 30, 2011·Antiviral Research·Suki M Y LeeJ S M Peiris
Oct 30, 2009·Trends in Immunology·Joseph Sriyal Malik PeirisJohn Malcolm Nicholls
Nov 26, 2009·Critical Care Medicine·James R SmithStephen Toovey
Aug 19, 2008·Lancet·Sheila M Bird, Jeremy Farrar
Mar 2, 2016·Journal of Epidemiology and Global Health·Catharina Y PraptiningsihTimothy M Uyeki
Sep 17, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Qing-Lin ChengLi Xie
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael C W ChanJ S Malik Peiris
Jul 19, 2012·Influenza and Other Respiratory Viruses·Herman KosasihEndang R Sedyaningsih
Jun 15, 2011·Influenza and Other Respiratory Viruses·Jessica A BelserFrederick G Hayden

❮ Previous
Next ❯

Related Concepts

Related Papers

The New England Journal of Medicine
Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian InfTimothy M Uyeki
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Nguyen Thanh LiemPeter Horby
The New England Journal of Medicine
I Nyoman KandunTimothy M Uyeki
The Journal of Infectious Diseases
Endang R SedyaningsihTriono Soendoro
© 2022 Meta ULC. All rights reserved