Factors associated with development and mortality of pulmonary hypertension in systemic lupus erythematosus patients

Lupus
J S KimS-C Bae

Abstract

Objectives This study aims to identify the factors associated with the development and mortality of pulmonary hypertension (PH) in systemic lupus erythematosus (SLE) patients. Methods We conducted a prospective study of SLE patients in a single tertiary center. PH was defined as a systolic pulmonary arterial pressure ≥30 mmHg on transthoracic echocardiography. We assessed potential associated factors contributing to the development and mortality of PH in SLE patients. Results Of 1110 patients with SLE, 48 patients were identified to have PH. Multivariable analysis indicated that pleuritis or pericarditis (odds ratio (OR) = 4.62), anti-RNP antibody (OR = 2.42), interstitial lung disease (ILD) (OR = 8.34) and cerebro-cardiovascular disease (OR = 13.37) were independently associated with the development of PH in SLE. Subgroup analysis among patients with PH demonstrated that there were no statistically significant factors associated with PH mortality in SLE. Conclusions The prevalence of PH was 4.3% in our cohort. There were significant associations with pleuritis or pericarditis, anti-RNP antibody, ILD, and cerebro-cardiovascular disease in SLE, which may contribute to the development of PH. However, there were no statistically s...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Aug 1, 1981·Seminars in Arthritis and Rheumatism·H D Perez, N Kramer
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Apr 30, 1999·Rheumatology International·J Y ShenQ Wang
Aug 25, 2000·Current Opinion in Pulmonary Medicine·G S Cheema, F P Quismorio
Jun 15, 2004·Journal of the American College of Cardiology·Robyn J BarstSean Gaine
Sep 9, 2004·Lupus·S R JohnsonJ T Granton
Feb 20, 2007·Lancet·David P D'CruzGraham R V Hughes
Jul 10, 2007·Respiratory Medicine·Gustavo A Heresi, Omar A Minai
Jun 3, 2008·The European Respiratory Journal·J Behr, J H Ryu
Oct 22, 2008·American Journal of Respiratory and Critical Care Medicine·Robin CondliffeJ Gerry Coghlan
Aug 13, 2009·Rheumatology·Athiveeraramapandian PrabuCaroline Gordon
Jul 31, 2012·Autoimmunity Reviews·Guillermo Ruiz-IrastorzaCiriaco Aguirre
Oct 23, 2012·International Journal of Rheumatic Diseases·Chan Hong JeonUNKNOWN pulmonary hypertension study group of Korean College of Rheumatology
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Benjamin E SchreiberJ Gerry Coghlan
Dec 21, 2013·Journal of the American College of Cardiology·Gerald SimonneauRogiero Souza
Jan 17, 2014·International Journal of Rheumatic Diseases·Ki-Jo KimChul-Soo Cho
May 6, 2014·The European Respiratory Journal·Yan-Jie HaoZhuo-Li Zhang

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Citations

Oct 20, 2018·Expert Review of Clinical Immunology·Vanessa Ocampo-PiraquiveGabriel J Tobón
Jan 8, 2020·Lupus Science & Medicine·Marisa MizusMichelle A Petri
Feb 12, 2019·Lupus·J Álvarez-Troncoso, A Robles-Marhuenda
Feb 20, 2021·Frontiers in Pediatrics·Ge DaiZhengrong Chen
Jun 16, 2021·Current Opinion in Pulmonary Medicine·Jürgen Behr, Steven D Nathan

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