Factors associated with disease activity of pouchitis after surgery for ulcerative colitis

Scandinavian Journal of Gastroenterology
J KuismaM Färkkilä

Abstract

Pouchitis occurs in 20% to 59% of patients operated on for ulcerative colitis. Several risk factors have been identified for the development of pouchitis. This study was undertaken to assess the incidence of pouchitis at least 5 years after ileal pouch-anal anastomosis for ulcerative colitis, and to evaluate possible predictive factors for inflammation activity. A total of 107 subjects were enrolled (54 M, 53 F, mean age 45 years, range 23-69) with a J-pouch created between 1985 and 1994. Preoperative medical history was determined, an endoscopy performed, and biopsies taken from the pouch and neoterminal ileum above the pouch. Sera from all patients were tested for perinuclear antineutrophil cytoplasmic antibodies (pANCAs). After a mean 7.5-years' follow-up time, the cumulative incidence of pouchitis was 58%. Risk for development of active inflammation (PDAI > or = 7) was significantly higher in patients with preoperative extraintestinal manifestations (OR 2.7, 95% CI 1.1-6.4, P=0.03). Patients who had had ankylosing spondylitis (AS) (OR 11.7, P=0.006) or iritis (OR 9.8, P=0.013) were especially at risk. Positive titres of pANCAs were associated with inflammation in the neoterminal ileum; 80% of patients with high pANCA levels...Continue Reading

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Citations

Apr 18, 2012·Nature Reviews. Gastroenterology & Hepatology·Bo Shen
Nov 2, 2012·The Journal of Pharmacology and Experimental Therapeutics·Shakir D AlSharariM Imad Damaj
Aug 10, 2012·World Journal of Gastroenterology : WJG·Eduard Cabré, Eugeni Domènech
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Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bo Shen
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Apr 17, 2012·Gastroenterology Clinics of North America·Yue Li, Bo Shen
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Dec 1, 2009·The Medical Clinics of North America·Hao Wu, Bo Shen
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Feb 2, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bo ShenVictor W Fazio
Dec 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Katherine FreemanBo Shen
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