PMID: 15250649Jul 15, 2004Paper

Factors associated with early-stage pulmonary fibrosis as determined by high-resolution computed tomography among persons occupationally exposed to asbestos

Scandinavian Journal of Work, Environment & Health
C ParisM Letourneux

Abstract

Asbestosis remains difficult to diagnose, particularly in its early stages. The aim of this study was to determine criteria for independently associated features of pulmonary fibrosis in high-resolution computed tomograms among persons occupationally exposed to asbestos. Retired persons with documented occupational asbestos exposure and no known asbestos-related diseases were assessed for occupational, clinical, functional respiratory, and chest X-ray criteria. In addition, they all underwent high-resolution computed tomography (HRCT) in the prone position. Altogether 51 (7.2%) of the 706 enrolled participants had features of pulmonary fibrosis consistent with asbestosis in the HRCT. Among those with small irregular opacities of <1/0 according to the 1980 International Labour Office Classification (ILO-C) in their X-rays, 5% had asbestosis in the HRCT. In a multivariate analysis, only age [odds ratio (OR) per year 1.08, 95% confidence interval (95% CI) 1.02-1.14], cumulative-exposure index (CEI) for asbestos (OR 6.4, 95% CI 1.5-28.4 for a CEI of > or =100 fibers/ml x years), and the presence of small irregular X-ray opacities of > or =1/0 ILO-C (OR 3.0, 95% CI 1.6-6.0) were independently associated with HRCT asbestosis. No comb...Continue Reading

Citations

Sep 17, 2009·International Archives of Occupational and Environmental Health·Tuula VierikkoTapio Vehmas
Jan 9, 2009·Mucosal Immunology·M S Wilson, T A Wynn
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Torsten BlumTorsten Bauer
Oct 28, 2010·BMC Public Health·Christophe ParisMarc Letourneux
Jul 28, 2011·Journal of Occupational Medicine and Toxicology·Dennis WilkenXaver Baur
Apr 25, 2012·Archives of Environmental & Occupational Health·Dionisios SpyratosLazaros Sichletidis
May 31, 2011·Journal de radiologie·G Ferretti
Jul 12, 2011·Revue des maladies respiratoires·J AmeilleJ-C Pairon
Jun 18, 2009·American Journal of Industrial Medicine·Giuseppe MastrangeloJohn H Lange
Feb 19, 2010·Respiratory Medicine·Lauri LehtimäkiEeva Moilanen
Jul 27, 2012·Respiratory Medicine·Sirpa Leivo-KorpelaEeva Moilanen
Jan 8, 2015·Journal of Occupational and Environmental Medicine·James E LockeyGrace K LeMasters
Feb 11, 2009·Journal of Thoracic Imaging·C Isabela S SilvaLuiz E Nery
Apr 4, 2017·American Journal of Industrial Medicine·Christian SchikowskyThomas Kraus
Jul 25, 2021·Journal of Clinical Medicine·François LaurentJean-Claude Pairon
Jan 25, 2008·Revue des maladies respiratoires·M LetourneuxF Galateau-Sallé

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