Factors associated with effectiveness of the first dose of hepatitis B vaccine in China: 1992-2005

Vaccine
Fuqiang CuiWeizhong Yang

Abstract

In China, the prevalence of chronic hepatitis B infection was high because of perinatal and early childhood transmission. A three-dose hepatitis B vaccine schedule with a first dose as soon as possible after birth was introduced in 1992 and generalized in 2002 in the Expanded Programme of Immunization (EPI). In 2006, a serological survey evaluated the effectiveness of vaccination. We conducted a restricted analysis of the national serological survey that sampled children and collected information on demographic characteristics, birth history, hepatitis B vaccination and hepatitis B surface antigen (HBsAg) status as determined by ELISA testing. We compared children who received the first dose in a timely way (i.e., within 24h of birth) with others in terms of HBsAg status, stratified by birth cohort and place of birth. Three-dose hepatitis B vaccine coverage increased from 60.8% for children born in 1992-1997 to 93.2% for children born in 2002-2005. Meanwhile, timely birth dose coverage increased from 38.7% to 74.4%. Among 29,410 children born in 1992-2005 who had received three vaccine doses and no hepatitis B immune globulin, factors associated with being HBsAg-negative in multivariate analysis included receiving a timely birt...Continue Reading

References

Sep 16, 2005·The New England Journal of Medicine·Jiang HePaul K Whelton
Jun 7, 2006·Epidemiologic Reviews·Colin W ShepardBeth P Bell

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Citations

Aug 17, 2011·International Journal of Public Health·Jonathan J ChenSamuel K S So
Dec 18, 2013·Vaccine·Xiaofeng LiangYu Wang
Dec 18, 2013·Vaccine·Stephen C HadlerYang Weizhong
Nov 22, 2015·Cancer Epidemiology·Patricia VillainRolando Herrero
Jun 20, 2015·Human Vaccines & Immunotherapeutics·Fuzhen WangFuqiang Cui
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Yan Cui, Jidong Jia
Jun 19, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Xiaona XinXu Ma
Aug 21, 2013·The American Journal of Tropical Medicine and Hygiene·Salah Thabit Al AwaidyMinal K Patel
Nov 8, 2019·Journal of Viral Hepatitis·Shevanthi NayagamMaud Lemoine
Jan 23, 2018·Open Forum Infectious Diseases·Alastair HeffernanSimon D Taylor-Robinson
Jul 27, 2020·Cost Effectiveness and Resource Allocation : C/E·Solomon Tessema MemirieTsinuel Girma
Nov 18, 2015·World Journal of Gastroenterology : WJG·Rosa ZampinoNicola Coppola

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