Factors associated with fasting plasma ghrelin levels in children and adolescents.

World Journal of Gastroenterology : WJG
Chao-Chun ZouZheng-Yan Zhao

Abstract

To measure plasma ghrelin levels in children and adolescents, analyze the associated factors, and investigate the role of ghrelin in obesity, insulin resistance and reproductive physiology. A total of 283 subjects aged 4.8-15.8 year were enrolled. Fasting blood samples were collected and plasma ghrelin levels were measured by radioimmunoassay. Fasting glucose (FG), fasting insulin (FI), baseline testosterone (T), estradiol (E2), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT) and uric acid (UA) were measured. Body mass index (BMI), insulin resistance by homeostasis model (HOMA-IR) and beta cell function by homeostasis model (HOMA-beta) were calculated. The median ghrelin level was 290 ng/L (15.0-1325.0 ng/L). Bivariate correlation analysis showed that ghrelin levels were inversely correlated with BMI, ALT, TG, UA, LH, FI and HOMA-IR (all P < 0.05). No other significant correlation was found between ghrelin levels and age, gender, TC, E2, FSH, PRL, FG and HOMA-beta. Stepwise multiple regression analysis showed that only BMI and FI were independent determinants of plasma ghrelin levels in these children and adolescents (...Continue Reading

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Citations

Nov 5, 2010·Indian Pediatrics·Nur ArslanAdem Aydin
Apr 30, 2011·World Journal of Gastroenterology : WJG·Francesco SavinoRoberto Oggero
Dec 24, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Leandro Soriano-GuillénCarmen Garcés
Jul 22, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M Gil-CamposA Gil
Mar 4, 2014·International Journal of Food Sciences and Nutrition·Yong Zhu, James H Hollis
Oct 26, 2013·Journal of Pediatric Gastroenterology and Nutrition·Prateek WaliKaroly Horvath

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