Factors associated with favourable outcome in large hemispheric infarctions

BMC Neurology
Jie LiMing Liu

Abstract

Large hemispheric infarction (LHI) is a devastating condition with high mortality and poor functional outcome in most conservatively treated patients. The purpose of this study was to explore factors associated with favorable outcome in patients with LHI. We prospectively enrolled consecutive patients with LHI. Favorable outcome was defined as a modified Rankin Scale (mRS) score of 0 to 3 at 90 days. Multivariate logistic regression analysis was employed to identify the independent factors associated with favorable outcome. Two hundred fifty-six cases with LHI were identified: 41 (16.0%) died during hospitalization, 94 (36.7%) died at 3 month, and 113 (44.1%) survived with favorable outcome at day 90. Compared with patients with unfavorable outcome, the favorable cases were younger (55.8 ± 14.7 vs. 66.2 ± 14.1), had less history of hypertension (38.9% vs. 59.3%), lower baseline NIHSS score (median NIHSS score 11 vs. 17), lower blood pressure on admission (systolic 134.7 ± 24.9 vs. 145.1 ± 26.1 mmHg; diastolic 80.2 ± 14.9 vs. 86.9 ± 16.2 mmHg; respectively), lower level of baseline serum glucose (7.2 ± 3.3 vs. 8.2 ± 3.3 mmol/L), a lower frequency of stroke-related complications (55.8% vs. 91.4%), more use of antiplatelets (93.8%...Continue Reading

References

Nov 1, 1995·Stroke; a Journal of Cerebral Circulation·R de HaanN Aaronson
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·H NakayamaT S Olsen
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·K C JohnstonE C Haley
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·S SchwabW Hacke
Oct 21, 1998·Archives of Physical Medicine and Rehabilitation·S N MacciocchiT Mertz
Feb 5, 1999·Stroke; a Journal of Cerebral Circulation·D W KriegerL Hantson
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·C J Vaughan, N Delanty
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·C OppenheimC Marsault
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·S E KasnerD W Krieger
Sep 12, 2001·Neurology·T SteinerW Hacke
Dec 11, 2002·European Heart Journal·P Di NapoliR De Caterina
Jun 5, 2003·Annals of Neurology·Jieli ChenMichael Chopp
Jul 12, 2003·Stroke; a Journal of Cerebral Circulation·Götz J ThomallaJoachim Röther
Jan 7, 2004·Stroke; a Journal of Cerebral Circulation·Rishi GuptaMitchell S V Elkind
Dec 6, 2005·Cerebrovascular Diseases·S Schwab
Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K-W WangC-H Lu
Feb 17, 2007·Lancet Neurology·Katayoun VahediUNKNOWN DECIMAL, DESTINY, and HAMLET investigators
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Juergen Bardutzky, Stefan Schwab
Jan 24, 2008·Cerebrovascular Diseases·Jeannette HofmeijerH Bart van der Worp
Jun 26, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Amer AlshekhleeSalvador Cruz-Flores
Oct 29, 2011·Stroke; a Journal of Cerebral Circulation·Ralph RahmeOpeolu Adeoye
Feb 11, 2012·Current Opinion in Critical Care·Katja E Wartenberg
Jan 5, 2013·Stroke; a Journal of Cerebral Circulation·Danielle Ní ChróinínPeter J Kelly
Mar 22, 2014·The New England Journal of Medicine·Eric JüttlerUNKNOWN DESTINY II Investigators
Mar 25, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xingyang YiWanzhang Chi
Apr 15, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Hermann Neugebauer, Eric Jüttler
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Feb 26, 2016·Neurology·Georgios TsivgoulisAndrei V Alexandrov

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Citations

Sep 14, 2019·Therapeutic Advances in Neurological Disorders·Jie LiChun Wang

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