Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography

Clinica Chimica Acta; International Journal of Clinical Chemistry
Jun-Sing WangWayne Huey-Herng Sheu

Abstract

We investigated factors associated with fibroblast growth factor 19 (FGF-19) increment after oral glucose loading (OGL) in human subjects. A total of 240 outpatients without known diabetes who were previously admitted for coronary angiography underwent an oral glucose tolerance test. FGF-19 increment (pg/ml) was calculated as FGF-19 2h after OGL minus fasting FGF-19. Overall, FGF-19 significantly increased after OGL (from 123 [78-201] to 141 [80-237], p=0.001). By age tertiles (≦ 54, 55-64, ≧ 65), FGF-19 significantly increased only in patients aged ≧ 65 (from 143 [98-209] to 189 [124-332], p<0.001). By glucose regulation status, FGF-19 significantly increased in patients with normal glucose tolerance (from 117 [78-211] to 153 [106-325], p=0.014) and in patients with prediabetes (from 117 [73-179] to 123 [70-204], p=0.043), but not in patients with diabetes (from 181 [102-243] to 178 [111-275], p=0.139). FGF-19 significantly increased in patients on statin treatment (from 120 [78-207] to 145 [86-264], p<0.001), but not in patients not on statin therapy (from 125 [86-196] to 128 [68-230] pg/ml, p=0.676). These findings remained significant after adjustment for confounders. FGF-19 increment after OGL was positively associated wit...Continue Reading

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Citations

Aug 21, 2018·Endocrine Reviews·Emmanuel Somm, François R Jornayvaz
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Lydia-Ann L S HarrisSamuel Klein
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuen-Kwun WongHung-Fat Tse

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