Factors associated with healing of artificial ulcer after endoscopic submucosal dissection with reference to Helicobacter pylori infection, CYP2C19 genotype, and tumor location: Multicenter randomized trial

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Yashiro YoshizawaTakahisa Furuta

Abstract

Healing speed of peptic ulcer is affected by a number of factors, including Helicobacter pylori (H. pylori) infection and intragastric pH. Acid inhibition exerted by proton pump inhibitors differs by CYP2C19 genotype. Herein, we investigated whether healing speed of artificial ulcers formed after endoscopic submucosal dissection (ESD) was influenced by H. pylori infection, CYP2C19 genotype, or other factors. A total of 96 H. pylori-positive patients with gastric tumors scheduled for ESD were randomly assigned to receive eradication therapy for H. pylori before ESD (pre-ESD eradication) (n = 44) or after (post-ESD eradication) (n = 52). Patients received eradication therapy consisting of lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 mg twice daily for 1 week. After ESD, lansoprazole 30 mg was given once daily for 8 weeks. Ulcer size was endoscopically measured on the next day and at 4 and 8 weeks after ESD. Mean reduction rate of artificial ulcer area in the pre-ESD eradication group was 94.7% ± 5.5% at 4 weeks, which was similar to that in the post-ESD eradication group (94.7% ± 6.7%, P = 0.987), irrespective of CYP2C19 genotype. In multivariate analyses, location of gastric tumor (middle and upper, odds ratio:...Continue Reading

References

Sep 24, 1999·Alimentary Pharmacology & Therapeutics·T Ishizaki, Y Horai
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·N ShiraiT Ishizaki
May 20, 2003·Alimentary Pharmacology & Therapeutics·P MalfertheinerUNKNOWN BYK Advanced Gastric Ulcer Study Group
Oct 8, 2004·Clinical Pharmacology and Therapeutics·Mitsushige SugimotoTakashi Ishizaki
Jul 1, 2005·Drug Metabolism and Pharmacokinetics·Takahisa FurutaTakashi Ishizaki
Aug 29, 2006·World Journal of Gastroenterology : WJG·Mitsuhiro Fujishiro
Dec 5, 2006·Gastrointestinal Endoscopy·Shiro OkaKazuaki Chayama
Feb 8, 2008·Digestion·Masaki TanakaKohei Takizawa
Apr 1, 2008·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroyuki OnoHiroyuki Matsubayashi
Jan 5, 2011·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tomofumi AkasakaNorio Hayashi
Mar 18, 2011·The Journal of Pharmacology and Experimental Therapeutics·Yasunobu HoriNobuhiro Inatomi
Feb 22, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Keiko NiimiKazuhiko Koike
Jan 22, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sang Gyun KimUNKNOWN Korean College of Helicobacter, Upper Gastrointestinal Research
Mar 6, 2015·Surgical Endoscopy·Joo Hyun LimHyun Chae Jung

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Citations

Aug 6, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke MaruokaOsamu Yokosuka
Mar 8, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Izumi TsuchiyaMotoyoshi Izumi
May 19, 2018·World Journal of Gastrointestinal Endoscopy·Taketo OtsukaAkira Andoh
Sep 27, 2018·World Journal of Gastroenterology : WJG·Hiromitsu BanAkira Andoh
Nov 19, 2019·BioMed Research International·Lan Li, Chaohui Yu
Oct 14, 2021·Clinical and Translational Gastroenterology·Mitsushige SugimotoTakashi Kawai

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