PMID: 8600699Jan 1, 1995Paper

Factors associated with high grade dysplasia and cancer in colorectal adenoma

Acta gastroenterologica Latinoamericana
G AlonsoA Currás

Abstract

The aim of this study was to assess the risk factors associated with high grade dysplasia (HGD) and cancer (CA) in colorectal polyps. We studied prospectively all colorectal polyps endoscopically resected from 6/91 to 12/93. Analyzed variables were age, sex and initial symptoms of patients, and number, localization, size and histologic characteristics of polyps. Adenomas were classified, according to the proportion of villous component, into tubular, villous A (1%-25% of villous component), villous B (26%-75%), villous C (76%-99%) and villous D 100%). One hundred polyps were resected from 67 patients (polyp/patient ratio:1.49). Mean age of patients was 63.9 +/- 10.3 year and 47 (70%) were men. Hematochezia was the main symptom (46%) and all of these patients had rectosigmoid polyps. Ninety three (93%) polyps were adenomas: Tubular 40 (43%), villous A 17 (18%), villous B 16 (17%), villous C 12 (13%) and villous D 8 (9%); 5 (5%) hyperplastic, 1 (1%) hammartoma and 1 (1%) inflammatory. Ten (11%) adenomas had foci of adenocarcinoma, 28 (30%) mild dysplasia, 42 (45%) moderate dysplasia and 20 (14%) high grade dysplasia. The percentage of villous C and D adenomas with cancer was 20% vs 3.6% of villous A adenomas (p: < 0.05) and 0% of...Continue Reading

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.