Factors Associated with High-sensitivity Cardiac Troponin T in Patients with Type 2 Diabetes Mellitus

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Takashi Hitsumoto

Abstract

The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is an established, useful biomarker for evaluating the pathogenesis of heart failure and predicting cardiovascular events. The aim of this study was to evaluate factors that are potentially associated with elevated blood hs-cTnT in patients with type 2 diabetes mellitus. Patients with type 2 diabetes mellitus (N=280, 111 men and 169 women; mean ± SD age: 71±9 years) with no history of cardiovascular events were enrolled. Relationships between hs-cTnT level and various clinical parameters were examined. Hs-cTnT was detected in 244 (87.1%) patients. There were no significant relationships between hs-cTnT and fasting blood glucose levels or insulin resistance. hs-cTnT was significantly correlated with advanced glycation end-product levels at the skin (r=0.23, p<0.001), blood concentrations of brain natriuretic peptide (r=0.23, p<0.001), reactive oxygen metabolites as markers of oxidative stress (r=0.28, p<0.001), and the augmentation index at the radial artery as marker of arterial reflection (r=0.31, p<0.001). Furthermore, multiple regression analysis revealed that these factors were also selected as independent variables, with hs-cTnT as a subordinate facto...Continue Reading

References

Mar 26, 2002·International Journal of Cardiology·Vicens MartíJosep M Augé
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·James J Oliver, David J Webb
Feb 4, 2005·Metabolism: Clinical and Experimental·Eun Seok KangHyun Chul Lee
Apr 19, 2006·Circulation·Thomas W WallaceJames A de Lemos
May 19, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenji TakazawaAkira Yamashina
Jan 29, 2008·Current Diabetes Reviews·Sho-ichi YamagishiTsutomu Imaizumi
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junko SogaYukihito Higashi
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Feb 25, 2010·Reviews in Endocrine & Metabolic Disorders·Sihem Boudina, Evan Dale Abel
Jun 17, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshiki FukuiYouichi Abe
Mar 9, 2012·International Heart Journal·Munehiro KamimuraMichiaki Hiroe
Sep 14, 2012·The Journal of International Medical Research·K KotaniN Sakane
Jan 8, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Takashi Hitsumoto
Feb 14, 2013·Heart Failure Reviews·Vijaya Lakshmi BodigaSreedhar Bodiga
Dec 7, 2013·Chemico-biological Interactions·Subramanian UmadeviVellaichamy Elangovan
Aug 15, 2014·Journal of Clinical and Diagnostic Research : JCDR·Namrata Bindurao KulkarniSudha Srikant Deo
Aug 26, 2014·Circulation·Elizabeth SelvinJosef Coresh

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.