Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis

Gastroenterology
Rohit LoombaBrent A Neuschwander-Tetri

Abstract

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation, and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in the NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disease activity score [NAS] by ≥2, with no worsening of fibrosis); 45% of patients had a histologic response to obeticholic acid (25 mg), and 21% had a response to placebo (P < .01). We performed a secondary analysis of data from this trial to identify clinical parameters associated with a histologic response. We used a logistic regression model with a stepwise selection procedure to identify baseline and early on-treatment factors associated with a histologic response at 72 weeks. Baseline demographics, liver histology, medical history, concomitant medications, cardiometabolic parameters, and serum biochemistry, as well as the changes over the course of the trial (at weeks 12 and 24), were evaluated as potential predictors of a histologic response. The model was cross-validated by a jackknife method, and performance was evaluated with the area under the receiver operating characteristic ...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Dec 17, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cecilia SöderbergRolf Hultcrantz
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRohit Loomba
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Jan 16, 2018·Alimentary Pharmacology & Therapeutics·B HameedUNKNOWN NASH CRN

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Citations

Jun 28, 2019·Alimentary Pharmacology & Therapeutics·Philip NewsomeArun Sanyal
Jan 24, 2019·World Journal of Gastroenterology : WJG·Naoki TanakaEiji Tanaka
Mar 3, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keyur PatelMazen Noureddin
Dec 14, 2019·Hepatology Communications·Samer GawriehUNKNOWN NASH Clinical Research Network
Jan 23, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit LoombaUNKNOWN NASH Clinical Research Network
Jul 28, 2020·Gastroenterology·Jose Miguel Ramos PittolSaskia W C van Mil
Nov 3, 2020·World Journal of Gastroenterology : WJG·Alejandro Campos-MurguíaRicardo U Macías-Rodríguez
Feb 15, 2021·Clinical Therapeutics·Shannon Kogachi, Mazen Noureddin
Mar 17, 2021·Clinics and Research in Hepatology and Gastroenterology·Anand V KulkarniNagaraja Rao Padaki
Sep 15, 2020·Gut and Liver·Soumya MuragDonghee Kim
Jun 17, 2021·Nature Reviews. Endocrinology·Daniel Ferguson, Brian N Finck
Jun 25, 2021·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:
Aug 13, 2021·The American Journal of Gastroenterology·Stephen A HarrisonManu V Chakravarthy

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