Abstract
Hyperhomocysteinaemia is a factor related to the development of atherosclerosis in rheumatoid arthritis (RA). However, Hispanics with RA develop high rates of coronary disease; there are no studies about the frequency and factors related to high levels of homocysteine in Mexican patients. To evaluate the prevalence and characteristics associated with hyperhomocysteinaemia in Mexican patients with RA. One hundred and fifty-two patients with RA were compared with 153 controls. The assessment in RA included clinical characteristics, disease activity (RADAR), functioning (HAQ-Di and global functional status), comorbidity, and radiological damage. Laboratory determinations included total serum homocysteine (tHcy), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and lipid profile. Median levels of homocysteine were higher in RA compared with controls (11.3 vs. 9.3, p<0.001). Twenty per cent of the patients with RA had hyperhomocysteinaemia (>15 micromol/L) compared with 6% in controls (p<0.001). There was statistical association between hyperhomocysteinaemia in RA with male gender (p<0.001), impairment in the global functional status (p = 0.004), higher radiological damage (p = 0.001), and CRP ...Continue Reading
References
May 1, 1992·Arthritis and Rheumatism·M C HochbergF Wolfe
Oct 4, 1995·JAMA : the Journal of the American Medical Association·C J BousheyA G Motulsky
Aug 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·M Krogh JensenL Svendsen
Apr 1, 1997·Arthritis and Rheumatism·R RoubenoffI H Rosenberg
Nov 17, 1998·The American Journal of Cardiology·J G CantoH V Barron
May 27, 1999·Annals of the Rheumatic Diseases·C J HaagsmaL B van de Putte
Sep 4, 1999·Annals of Internal Medicine·J SelhubC L Johnson
Sep 22, 1999·Heart·P H WhincupS B Ebrahim
Feb 18, 2003·Journal of the American Dietetic Association·Setareh Torabian EsfahaniMarie A Caudill
Mar 12, 2003·Circulation·Daniel H SolomonGary C Curhan
Dec 21, 2004·Annals of the Rheumatic Diseases·M HoekstraM A F J van de Laar
Citations
Aug 23, 2008·Rheumatology International·Laura Gonzalez-LopezJorge I Gamez-Nava
Aug 2, 2012·Therapeutic Advances in Musculoskeletal Disease·Jonathan L Marks, Christopher J Edwards
Sep 14, 2010·Journal of Periodontology·Rosamma JosephM G Joseraj
Jul 28, 2007·Scandinavian Journal of Rheumatology·D J ArmstrongG D Wright
Aug 30, 2011·Immunobiology·Iztok HolcArtur Pahor
Sep 9, 2015·Biomarker Research·Mickael Essouma, Jean Jacques N Noubiap
Nov 26, 2015·Scandinavian Journal of Rheumatology·T DimitroulasG D Kitas
Mar 4, 2008·Journal of the American Dietetic Association·Kathleen Woolf, Melinda M Manore
Nov 30, 2012·Arthritis·Juan Camilo Sarmiento-MonroyAdriana Rojas-Villarraga
Sep 11, 2013·Scandinavian Journal of Rheumatology·A Nowakowska-PlazaA Undas
Sep 2, 2014·BioMed Research International·Jenny Amaya-AmayaAdriana Rojas-Villarraga
Jul 18, 2016·Clinical Rheumatology·Han CenRen-Jie Zhuo
May 7, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Imane El BouchtiJean Sibilia
Jul 24, 2007·Autoimmunity Reviews·Pietro Enea LazzeriniFranco Laghi Pasini
Nov 1, 2007·Lupus·P E LazzeriniF Laghi Pasini
Mar 17, 2009·Rheumatology International·Bedriye Mermerci BaşkanHatice Bodur
Apr 16, 2013·Immunologic Research·Jenny Amaya-AmayaJuan-Manuel Anaya
Dec 17, 2014·Clinical Chemistry·Alphonsus H C NgAaron R Wheeler
Feb 29, 2020·Journal of Clinical Periodontology·H Gencay KeceliEbru Olgun
Oct 2, 2020·International Heart Journal·Yingxian LiuShuyang Zhang
May 28, 2019·Frontiers in Neurology·Lizhi LiuYing Jiang
Mar 15, 2020·Clinical Rheumatology·Zahra Bagheri-HosseinabadiMitra Abbasifard
Mar 12, 2021·Advances in Rheumatology·Hui-Hui LiYing-Jie Zhao
Mar 30, 2021·Contemporary Clinical Dentistry·Gautami S PenmetsaAnudeep Mopidevi
Sep 28, 2021·Zeitschrift für Rheumatologie·Rawdha TekayaLeila Abdelmoula