Factors associated with hyperhomocysteinaemia in Mexican patients with rheumatoid arthritis

Scandinavian Journal of Rheumatology
M A Lopez-OlivoJ I Gamez-Nava

Abstract

Hyperhomocysteinaemia is a factor related to the development of atherosclerosis in rheumatoid arthritis (RA). However, Hispanics with RA develop high rates of coronary disease; there are no studies about the frequency and factors related to high levels of homocysteine in Mexican patients. To evaluate the prevalence and characteristics associated with hyperhomocysteinaemia in Mexican patients with RA. One hundred and fifty-two patients with RA were compared with 153 controls. The assessment in RA included clinical characteristics, disease activity (RADAR), functioning (HAQ-Di and global functional status), comorbidity, and radiological damage. Laboratory determinations included total serum homocysteine (tHcy), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and lipid profile. Median levels of homocysteine were higher in RA compared with controls (11.3 vs. 9.3, p<0.001). Twenty per cent of the patients with RA had hyperhomocysteinaemia (>15 micromol/L) compared with 6% in controls (p<0.001). There was statistical association between hyperhomocysteinaemia in RA with male gender (p<0.001), impairment in the global functional status (p = 0.004), higher radiological damage (p = 0.001), and CRP ...Continue Reading

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Citations

Aug 23, 2008·Rheumatology International·Laura Gonzalez-LopezJorge I Gamez-Nava
Aug 2, 2012·Therapeutic Advances in Musculoskeletal Disease·Jonathan L Marks, Christopher J Edwards
Sep 14, 2010·Journal of Periodontology·Rosamma JosephM G Joseraj
Jul 28, 2007·Scandinavian Journal of Rheumatology·D J ArmstrongG D Wright
Mar 4, 2008·Journal of the American Dietetic Association·Kathleen Woolf, Melinda M Manore
Nov 30, 2012·Arthritis·Juan Camilo Sarmiento-MonroyAdriana Rojas-Villarraga
Sep 2, 2014·BioMed Research International·Jenny Amaya-AmayaAdriana Rojas-Villarraga
May 7, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Imane El BouchtiJean Sibilia
Jul 24, 2007·Autoimmunity Reviews·Pietro Enea LazzeriniFranco Laghi Pasini
Mar 17, 2009·Rheumatology International·Bedriye Mermerci BaşkanHatice Bodur
Apr 16, 2013·Immunologic Research·Jenny Amaya-AmayaJuan-Manuel Anaya
Mar 15, 2020·Clinical Rheumatology·Zahra Bagheri-HosseinabadiMitra Abbasifard

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