Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience

The Journal of Clinical Endocrinology and Metabolism
Philip C JohnstonBetul A Hatipoglu

Abstract

Total pancreatectomy (TP) with islet cell autotransplantation (IAT) can reduce or prevent diabetes by preserving beta cell function and is normally performed with on-site isolation laboratory facilities. We examined factors associated with islet yield and metabolic outcomes in patients with chronic pancreatitis undergoing TP-IAT. We report our experience of TP-IAT with an off-site islet isolation laboratory. Data (August 2008 to February 2014) were obtained from a TP-IAT database which included information from medical records, clinic visits, questionnaires, and follow-up telephone calls. Each patient was assessed with pre- and postoperative 5-hour mixed-meal tolerance tests for metabolic measurements and with serial glycosylated hemoglobin (HbA1c) determinations. Thirty-six patients with a mean age of 38 years (range, 16-72 y) underwent TP-IAT for different etiologies. At a median follow-up time of 28 months (range, 3-66 mo), 12 patients were insulin independent and 24 patients were on at least one insulin injection a day. Postoperatively, C-peptide levels ≥0.3 ng/mL were present in 23/33 (70%) of the patients, with a median fasting C-peptide value of 0.8 ng/mL (range, <0.2-1.5 ng/mL). Those who were insulin independent were m...Continue Reading

Citations

Aug 17, 2016·Current Stem Cell Reports·Asako TajimaYong Fan
Jun 19, 2015·Pediatric Diabetes·Rita Bottino, Massimo Trucco
Feb 12, 2017·Pancreas·Myfanwy Clare GeyerRichard Thomas Lee Couper
Sep 25, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K BenomarM C Vantyghem
Oct 11, 2016·World Journal of Gastrointestinal Surgery·Hazem M ZakariaHoracio J Asbun
Nov 22, 2017·Stem Cells Translational Medicine·Hongjun WangKatherine A Morgan
Nov 30, 2018·European Journal of Gastroenterology & Hepatology·Minas BaltatzisAjith K Siriwardena
Dec 13, 2018·Endocrine Reviews·Michael R Rickels, R Paul Robertson
Aug 23, 2016·The Journal of Clinical Endocrinology and Metabolism·Yu Kuei LinBetul A Hatipoglu
May 9, 2015·The Journal of Clinical Endocrinology and Metabolism·R Paul Robertson
Feb 19, 2020·Artificial Organs·Qiang LiuCristiano Quintini
Jul 19, 2017·Current Opinion in Organ Transplantation·Yoshitaro Shindo, Mazhar A Kanak
Jun 25, 2016·Current Opinion in Gastroenterology·Walter G Park
Oct 2, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Siddharth NarayananChristopher M Jones
Sep 9, 2016·Updates in Surgery·Marco Del ChiaroUrban Arnelo
Aug 28, 2020·World Journal of Diabetes·Ayan RoyBiju Pottakkat
Nov 7, 2019·Journal of Diabetes Research·Philip C JohnstonIan Wallace
Feb 9, 2017·The American Journal of Gastroenterology·Samuel J KesseliTimothy B Gardner
Sep 30, 2018·Current Diabetes Reports·Mohammed E Al-SofianiRita Rastogi Kalyani
Jul 31, 2018·Frontiers in Medicine·Rita BottinoMassimo M Trucco
Dec 20, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Andrew T TroutJaimie D Nathan
Dec 4, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Robert NaplesRobert Simon
Apr 25, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Maisam Abu-El-HaijaMelena D Bellin
Mar 6, 2021·Current Problems in Surgery·Thomas K Maatman, Nicholas J Zyromski
Mar 6, 2021·Current Problems in Surgery·Thomas K Maatman, Nicholas J Zyromski
Mar 24, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yoshihide NannoMelena D Bellin
Apr 28, 2021·Cell Transplantation·Srividya VasuMelena D Bellin
May 1, 2021·Antioxidants·Lourdes SwentekHirohito Ichii
Jul 6, 2021·Annals of Pediatric Endocrinology & Metabolism·Inderpal Singh Kochar, Rakhi Jain
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers

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