Factors associated with long-term survival in central nervous system metastases

Journal of Neuro-oncology
Bernardo Cacho-DíazOscar Arrieta

Abstract

Cancer is a leading cause of death worldwide; central nervous system metastases (CNSm) are amongst the most common complications of cancer and are associated with high morbidity and mortality. The aim of the study was to associate clinic and oncologic characteristics with the possibility of survival for ≥ 1 year. A prospective cohort in two referral centers recollected clinical and oncologic data from patients diagnosed with CNSm. Chronic metastases were defined as those patients that survived for ≥ 12 months after the diagnosis of CNSm. Of 613 patients with CNSm, 554 had solid tumors as the primary cancer and were included; 405 (73%) were women, the most common primary cancer site were breast, lung and urologic. Chronic CNSm were found in 260 (47%) and were compared to those who did not. After multivariate logistic regression analysis, variables associated with good prognosis (living > 12 months) were: female sex (HR 0.55), single CNSm (HR 0.39), diagnosis of CNSm during initial extension studies or during presentation of cancer (HR 0.43), and occipital location (HR 0.62). Long-term survival in patients with CNSm remains a topic of debate; their bad prognosis could be changing towards improvement. Clinical findings are typical...Continue Reading

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Citations

Jan 5, 2020·Journal of Translational Medicine·Bernardo Cacho-DíazLuis Alonso Herrera-Montalvo
Jan 20, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K Holub, G Louvel
Jan 7, 2021·Molecular Cancer Therapeutics·Ethan S SrinivasanMustafa Khasraw
Mar 24, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·T BerberH Ohyoshi

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