Factors associated with lung function decline in patients with non-tuberculous mycobacterial pulmonary disease

PloS One
Meng-Rui LeeChong-Jen Yu

Abstract

There is paucity of risk factors on lung function decline among patients with non-tuberculous mycobacteria (NTM) pulmonary disease in literature. Patients with NTM pulmonary disease between January 2000 and April 2011 were retrospectively selected. Sixty-eight patients had at least two pulmonary function tests within a mean follow-up period of 47 months. Sixty-eight patients were included. They had a median age of 65 years and 65% had impaired lung function (Forced expiratory volume in 1 second [FEV1] <80% of predicted value). The mean FEV1 decline was 48 ml/year. By linear regression, younger age (beta: 0.472, p<0.001), initial FEV1>50% of predicted value (beta: 0.349, p = 0.002), male sex (beta: 0.295, p = 0.018), bronchiectasis pattern (beta: 0.232, p = 0.035), and radiographic score >3 (beta: 0.217, p = 0.049) were associated with greater FEV1 decline. Initial FEV1>50% of predicted value (beta: 0.263, p = 0.032) was also associated with greater FVC annual decline, whereas M. kansasii pulmonary disease was marginally associated with greater annual FVC decline (beta: 0.227, p = 0.062). NTM pulmonary disease is associated with greater decline in lung function in patients who are young, male, with bronchiectasis, and with a hig...Continue Reading

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Related Concepts

Bronchiectasis
Forced Expiratory Flow Rates
Lung Diseases
Atypical Mycobacterial Infection, Disseminated
Retrospective Studies
Log-Linear Models
Attention
Literature
Genus Mycobacterium
Respiratory Physiology

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