Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda

PloS One
Adoke YekaSarah G Staedke

Abstract

Understanding the current epidemiology of malaria and the relationship between intervention coverage, transmission intensity, and burden of disease is important to guide control activities. We aimed to determine the prevalence of anemia, parasitemia, and serological responses to P. falciparum antigens, and factors associated with these indicators, in three different epidemiological settings in Uganda. In 2012, cross-sectional surveys were conducted in 200 randomly selected households from each of three sites: Walukuba, Jinja district (peri-urban); Kihihi, Kanungu district (rural); and Nagongera, Tororo district (rural) with corresponding estimates of annual entomologic inoculation rates (aEIR) of 3.8, 26.6, and 125.0, respectively. Of 2737 participants, laboratory testing was done in 2227 (81.4%), including measurement of hemoglobin, parasitemia using microscopy, and serological responses to P. falciparum apical membrane antigen 1 (AMA-1) and merozoite surface protein 1, 19 kilodalton fragment (MSP-119). Analysis of laboratory results was restricted to 1949 (87.5%) participants aged ≤ 40 years. Prevalence of anemia (hemoglobin < 11.0 g/dL) was significantly higher in Walukuba (18.9%) and Nagongera (17.4%) than in Kihihi (13.1%)...Continue Reading

Associated Clinical Trials

Dec 9, 2020·College of Health Sciences

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Citations

Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Christopher L KingBryan Greenhouse
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Caroline A LynchJonathan Cox
Oct 10, 2018·The American Journal of Tropical Medicine and Hygiene·Bryan GreenhouseChris J Drakeley
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Apr 16, 2021·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Pross Nagitta OlukaGeorge William Kajjumba

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